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  1. The sensitivity of chronic lymphocytic leukemia (CLL) cells to current treatments, both in vitro and in vivo, relies on their ability to activate apoptotic death. CLL cells resistant to DNA damage-induced apoptos...

    Authors: Jean-Brice Marteau, Odile Rigaud, Thibaut Brugat, Nathalie Gault, Laurent Vallat, Mogens Kruhoffer, Torben F Orntoft, Florence Nguyen-Khac, Sylvie Chevillard, Hélène Merle-Beral and Jozo Delic
    Citation: BMC Medical Genomics 2010 3:53
    Content type: Research article Published on:

  2. The advent of gene expression profiling was expected to dramatically improve cancer diagnosis. However, despite intensive efforts and several successful examples, the development of profile-based diagnostic sy...

    Authors: Satoru Kawarazaki, Kazuya Taniguchi, Mitsuaki Shirahata, Yoji Kukita, Manabu Kanemoto, Nobuhiro Mikuni, Nobuo Hashimoto, Susumu Miyamoto, Jun A Takahashi and Kikuya Kato
    Citation: BMC Medical Genomics 2010 3:52
    Content type: Technical advance Published on:

  3. Despite extensive research, the details of the biological mechanisms by which cancer cells acquire motility and invasiveness are largely unknown. This study identifies an invasion associated gene signature she...

    Authors: Hoon Kim, John Watkinson, Vinay Varadan and Dimitris Anastassiou
    Citation: BMC Medical Genomics 2010 3:51
    Content type: Research article Published on:

  4. Disease-specific genetic information has been increasing at rapid rates as a consequence of recent improvements and massive cost reductions in sequencing technologies. Numerous systems designed to capture and ...

    Authors: Dennis P Wall, Rimma Pivovarov, Mark Tong, Jae-Yoon Jung, Vincent A Fusaro, Todd F DeLuca and Peter J Tonellato
    Citation: BMC Medical Genomics 2010 3:50
    Content type: Software Published on:

  5. Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the gene...

    Authors: Junguk Hur, Kelli A Sullivan, Adam D Schuyler, Yu Hong, Manjusha Pande, David J States, H V Jagadish and Eva L Feldman
    Citation: BMC Medical Genomics 2010 3:49
    Content type: Research article Published on:

  6. HCV infection frequently induces chronic liver diseases. The current standard treatment for chronic hepatitis (CH) C combines pegylated interferon (IFN) and ribavirin, and is less than ideal due to undesirable...

    Authors: Yoshiki Murakami, Masami Tanaka, Hidenori Toyoda, Katsuyuki Hayashi, Masahiko Kuroda, Atsushi Tajima and Kunitada Shimotohno
    Citation: BMC Medical Genomics 2010 3:48
    Content type: Research article Published on:

  7. The question of a genetic contribution to the higher prevalence and incidence of end stage kidney disease (ESKD) among African Americans (AA) remained unresolved, until recent findings using admixture mapping ...

    Authors: Liran I Shlush, Sivan Bercovici, Walter G Wasser, Guennady Yudkovsky, Alan Templeton, Dan Geiger and Karl Skorecki
    Citation: BMC Medical Genomics 2010 3:47
    Content type: Research article Published on:

  8. Immunization of BALB/c mice with a recombinant adenovirus expressing Mycobacterium tuberculosis (M. tuberculosis) antigen 85A (Ad85A) protects against aerosol challenge with M. tuberculosis only when it is admini...

    Authors: Lian N Lee, Dilair Baban, Edward O Ronan, Jiannis Ragoussis, Peter CL Beverley and Elma Z Tchilian
    Citation: BMC Medical Genomics 2010 3:46
    Content type: Research article Published on:

  9. The prevalence of diabetes is increasing worldwide. It has been long known that increased rates of inflammatory diseases, such as obesity (OBS), hypertension (HT) and cardiovascular diseases (CVD) are highly a...

    Authors: Jesmin, Mahbubur SM Rashid, Hasan Jamil, Raquel Hontecillas and Josep Bassaganya-Riera
    Citation: BMC Medical Genomics 2010 3:45
    Content type: Research article Published on:

  10. HSP90 may be a favorable target for investigational therapy in breast cancer. In fact, the HSP90 inhibitor, 17AAG, currently has entered in phase II clinical trials as an anticancer agent in breast and other t...

    Authors: Magdalena Zajac, Gonzalo Gomez, Javier Benitez and Beatriz Martínez-Delgado
    Citation: BMC Medical Genomics 2010 3:44
    Content type: Research article Published on:

  12. Studies in mothers of Down syndrome individuals (MDS) point to a role for polymorphisms in folate metabolic genes in increasing chromosome damage and maternal risk for a Down syndrome (DS) pregnancy, suggestin...

    Authors: Fabio Coppedè, Enzo Grossi, Francesca Migheli and Lucia Migliore
    Citation: BMC Medical Genomics 2010 3:42
    Content type: Research article Published on:

  13. Decubitus ulcers, also known as bedsores or pressure ulcers, affect millions of hospitalized patients each year. The microflora of chronic wounds such as ulcers most commonly exist in the biofilm phenotype and...

    Authors: Drake M Smith, David E Snow, Eric Rees, Ann M Zischkau, J Delton Hanson, Randall D Wolcott, Yan Sun, Jennifer White, Shashi Kumar and Scot E Dowd
    Citation: BMC Medical Genomics 2010 3:41
    Content type: Research article Published on:

  14. Pathological angiogenesis represents a critical issue in the progression of many diseases. Down syndrome is postulated to be a systemic anti-angiogenesis disease model, possibly due to increased expression of ...

    Authors: Valerio Costa, Linda Sommese, Amelia Casamassimi, Roberta Colicchio, Claudia Angelini, Valentina Marchesano, Lara Milone, Bartolomeo Farzati, Alfonso Giovane, Carmela Fiorito, Monica Rienzo, Marco Picardi, Bice Avallone, Massimiliano Marco Corsi, Berardo Sarubbi, Raffaele Calabrò…
    Citation: BMC Medical Genomics 2010 3:40
    Content type: Research article Published on:

  15. Tumor therapy mainly attacks the metabolism to interfere the tumor's anabolism and signaling of proliferative second messengers. However, the metabolic demands of different cancers are very heterogeneous and d...

    Authors: Gunnar Schramm, Eva-Maria Surmann, Stefan Wiesberg, Marcus Oswald, Gerhard Reinelt, Roland Eils and Rainer König
    Citation: BMC Medical Genomics 2010 3:39
    Content type: Research article Published on:

  16. According to the Genetic Analysis Workshops (GAW), hundreds of thousands of SNPs have been tested for association with rheumatoid arthritis. Traditional genome-wide association studies (GWAS) have been develop...

    Authors: Liangcai Zhang, Wan Li, Leilei Song and Lina Chen
    Citation: BMC Medical Genomics 2010 3:38
    Content type: Research article Published on:

  17. Drinking water contaminated with inorganic arsenic is associated with increased risk for different types of cancer. Paradoxically, arsenic trioxide can also be used to induce remission in patients with acute p...

    Authors: Qian Liu, Hao Zhang, Lisa Smeester, Fei Zou, Matt Kesic, Ilona Jaspers, Jingbo Pi and Rebecca C Fry
    Citation: BMC Medical Genomics 2010 3:37
    Content type: Research article Published on:

  18. Gene expression profiling is a highly sensitive technique which is used for profiling tumor samples for medical prognosis. RNA quality and degradation influence the analysis results of gene expression profiles...

    Authors: Lennart Opitz, Gabriela Salinas-Riester, Marian Grade, Klaus Jung, Peter Jo, Georg Emons, B Michael Ghadimi, Tim Beißbarth and Jochen Gaedcke
    Citation: BMC Medical Genomics 2010 3:36
    Content type: Research article Published on:

  20. Excessive accumulation of body fat, in particular in the visceral fat depot, is a major risk factor to develop a variety of diseases such as type 2 diabetes. The mechanisms underlying the increased risk of obe...

    Authors: Marcel GM Wolfs, Sander S Rensen, Elinda J Bruin-Van Dijk, Froukje J Verdam, Jan-Willem Greve, Bahram Sanjabi, Marcel Bruinenberg, Cisca Wijmenga, Timon W van Haeften, Wim A Buurman, Lude Franke and Marten H Hofker
    Citation: BMC Medical Genomics 2010 3:34
    Content type: Research article Published on:

  21. Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome...

    Authors: Christopher G Bell, Andrew E Teschendorff, Vardhman K Rakyan, Alexander P Maxwell, Stephan Beck and David A Savage
    Citation: BMC Medical Genomics 2010 3:33
    Content type: Research article Published on:

  22. An important consideration when analyzing both microarray and quantitative PCR expression data is the selection of appropriate genes as endogenous controls or reference genes. This step is especially critical ...

    Authors: Raj Chari, Kim M Lonergan, Larissa A Pikor, Bradley P Coe, Chang Qi Zhu, Timothy HW Chan, Calum E MacAulay, Ming-Sound Tsao, Stephen Lam, Raymond T Ng and Wan L Lam
    Citation: BMC Medical Genomics 2010 3:32
    Content type: Research article Published on:

  23. The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. To understand early signaling and gene regulation in bystander cells,...

    Authors: Shanaz A Ghandhi, Lihua Ming, Vladimir N Ivanov, Tom K Hei and Sally A Amundson
    Citation: BMC Medical Genomics 2010 3:31
    Content type: Research article Published on:

  24. Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytop...

    Authors: Mariana O Baratti, Yuri B Moreira, Fabiola Traina, Fernando F Costa, Sergio Verjovski-Almeida and Sara T Olalla-Saad
    Citation: BMC Medical Genomics 2010 3:30
    Content type: Research article Published on:

  25. This investigation offers insights into system-wide pathological processes induced in response to cigarette smoke exposure by determining its influences at the gene expression level.

    Authors: Jac C Charlesworth, Joanne E Curran, Matthew P Johnson, Harald HH Göring, Thomas D Dyer, Vincent P Diego, Jack W Kent Jr, Michael C Mahaney, Laura Almasy, Jean W MacCluer, Eric K Moses and John Blangero
    Citation: BMC Medical Genomics 2010 3:29
    Content type: Research article Published on:

  26. ATRX is a severe X-linked disorder characterized by mental retardation, facial dysmorphism, urogenital abnormalities and alpha-thalassemia. The disease is caused by mutations in ATRX gene, which encodes a prot...

    Authors: Vincenza Barresi, Angela Ragusa, Marco Fichera, Nicolò Musso, Lucia Castiglia, Giancarlo Rappazzo, Salvatore Travali, Teresa Mattina, Corrado Romano, Guido Cocchi and Daniele F Condorelli
    Citation: BMC Medical Genomics 2010 3:28
    Content type: Research article Published on:

  27. Cerebral ischemia/reperfusion injury is a common secondary effect of cardiac arrest which is largely responsible for postresuscitative mortality. Therefore development of therapies which restore and protect th...

    Authors: Cécile Martijn and Lars Wiklund
    Citation: BMC Medical Genomics 2010 3:27
    Content type: Research article Published on:

  28. Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation ...

    Authors: Andrey Loboda, Michael Nebozhyn, Rich Klinghoffer, Jason Frazier, Michael Chastain, William Arthur, Brian Roberts, Theresa Zhang, Melissa Chenard, Brian Haines, Jannik Andersen, Kumiko Nagashima, Cloud Paweletz, Bethany Lynch, Igor Feldman, Hongyue Dai…
    Citation: BMC Medical Genomics 2010 3:26
    Content type: Research article Published on:

  31. Cancer is a heterogeneous disease caused by genomic aberrations and characterized by significant variability in clinical outcomes and response to therapies. Several subtypes of common cancers have been identif...

    Authors: Xin Lu, Ke Zhang, Charles Van Sant, John Coon and Dimitri Semizarov
    Citation: BMC Medical Genomics 2010 3:23
    Content type: Research article Published on:

  32. The inability of aspirin (ASA) to adequately suppress platelet aggregation is associated with future risk of coronary artery disease (CAD). Heritability studies of agonist-induced platelet function phenotypes ...

    Authors: Rasika A Mathias, Yoonhee Kim, Heejong Sung, Lisa R Yanek, VJ Mantese, J Enrique Hererra-Galeano, Ingo Ruczinski, Alexander F Wilson, Nauder Faraday, Lewis C Becker and Diane M Becker
    Citation: BMC Medical Genomics 2010 3:22
    Content type: Research article Published on:

  33. In translational cancer research, gene expression data is collected together with clinical data and genomic data arising from other chip based high throughput technologies. Software tools for the joint analysi...

    Authors: Alexander Gribov, Martin Sill, Sonja Lück, Frank Rücker, Konstanze Döhner, Lars Bullinger, Axel Benner and Antony Unwin
    Citation: BMC Medical Genomics 2010 3:21
    Content type: Software Published on:

  35. Development in systems biology research has accelerated in recent years, and the reconstructions for molecular networks can provide a global view to enable in-depth investigation on numerous system properties ...

    Authors: Shih-Kuang Yang, Yu-Chao Wang, Chun-Cheih Chao, Yung-Jen Chuang, Chung-Yu Lan and Bor-Sen Chen
    Citation: BMC Medical Genomics 2010 3:19
    Content type: Research article Published on:

  36. The term endothelial progenitor cells (EPCs) is currently used to refer to cell populations which are quite dissimilar in terms of biological properties. This study provides a detailed molecular fingerprint fo...

    Authors: Reinhold J Medina, Christina L O'Neill, Mark Sweeney, Jasenka Guduric-Fuchs, Tom A Gardiner, David A Simpson and Alan W Stitt
    Citation: BMC Medical Genomics 2010 3:18
    Content type: Research article Published on:

  38. MUC1 protein is highly expressed in lung cancer. The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional changes a...

    Authors: Dhara M MacDermed, Nikolai N Khodarev, Sean P Pitroda, Darrin C Edwards, Charles A Pelizzari, Lei Huang, Donald W Kufe and Ralph R Weichselbaum
    Citation: BMC Medical Genomics 2010 3:16
    Content type: Research article Published on:

  39. Chronic inflammatory diseases including inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), psoriasis and rheumatoid arthritis (RA) afflict millions of people worldwide, but their pathoge...

    Authors: Bertalan Mesko, Szilard Poliskal, Andrea Szegedi, Zoltan Szekanecz, Karoly Palatka, Maria Papp and Laszlo Nagy
    Citation: BMC Medical Genomics 2010 3:15
    Content type: Research article Published on:

  40. The development and progression of cancer depend on its genetic characteristics as well as on the interactions with its microenvironment. Understanding these interactions may contribute to diagnostic and progn...

    Authors: Flávia C Rodrigues-Lisoni, Paulo Peitl Jr, Alessandra Vidotto, Giovana M Polachini, José V Maniglia, Juliana Carmona-Raphe, Bianca R Cunha, Tiago Henrique, Caique F Souza, Rodrigo AP Teixeira, Erica E Fukuyama, Pedro Michaluart Jr, Marcos B de Carvalho, Sonia M Oliani and Eloiza H Tajara
    Citation: BMC Medical Genomics 2010 3:14
    Content type: Research article Published on:

  42. Trisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit features of cancer stem cells. Since ...

    Authors: Sailesh Gopalakrishna-Pillai and Linda E Iverson
    Citation: BMC Medical Genomics 2010 3:12
    Content type: Research article Published on:

  43. Genomic copy number alterations are widely associated with a broad range of human tumors and offer the potential to be used as a diagnostic tool. Especially in the emerging era of personalized medicine medical...

    Authors: Yuri Kotliarov, Serdar Bozdag, Hangjiong Cheng, Stefan Wuchty, Jean-Claude Zenklusen and Howard A Fine
    Citation: BMC Medical Genomics 2010 3:11
    Content type: Software Published on:

  44. One consistent finding in autism spectrum disorders (ASD) is a decreased level of the pineal gland hormone melatonin and it has recently been demonstrated that this decrease to a large extent is due to low act...

    Authors: Lina Jonsson, Elin Ljunggren, Anna Bremer, Christin Pedersen, Mikael Landén, Kent Thuresson, MaiBritt Giacobini and Jonas Melke
    Citation: BMC Medical Genomics 2010 3:10
    Content type: Research article Published on:

  45. Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived from breasts with more than 50% density. Mammograp...

    Authors: Margarethe Biong, Inger T Gram, Ilene Brill, Fredrik Johansen, Hiroko K Solvang, Grethe IG Alnaes, Toril Fagerheim, Yngve Bremnes, Stephen J Chanock, Laurie Burdett, Meredith Yeager, Giske Ursin and Vessela N Kristensen
    Citation: BMC Medical Genomics 2010 3:9
    Content type: Research article Published on:

  46. Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict dise...

    Authors: Andrea Sboner, Francesca Demichelis, Stefano Calza, Yudi Pawitan, Sunita R Setlur, Yujin Hoshida, Sven Perner, Hans-Olov Adami, Katja Fall, Lorelei A Mucci, Philip W Kantoff, Meir Stampfer, Swen-Olof Andersson, Eberhard Varenhorst, Jan-Erik Johansson, Mark B Gerstein…
    Citation: BMC Medical Genomics 2010 3:8
    Content type: Research article Published on:

  47. Public proteomics databases such as PeptideAtlas contain peptides and proteins identified in mass spectrometry experiments. However, these databases lack information about human disease for researchers studyin...

    Authors: Jeremy Handcock, Eric W Deutsch and John Boyle
    Citation: BMC Medical Genomics 2010 3:7
    Content type: Software Published on:

  48. Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnorm...

    Authors: Anna Andersson, Patrik Edén, Tor Olofsson and Thoas Fioretos
    Citation: BMC Medical Genomics 2010 3:6
    Content type: Research article Published on:

  49. Chronic systemic low-grade inflammation in obese subjects is associated with health complications including cardiovascular diseases, insulin resistance and diabetes. Reducing inflammatory responses may reduce ...

    Authors: Marjan J van Erk, Suzan Wopereis, Carina Rubingh, Trinette van Vliet, Elwin Verheij, Nicole HP Cnubben, Theresa L Pedersen, John W Newman, Age K Smilde, Jan van der Greef, Henk FJ Hendriks and Ben van Ommen
    Citation: BMC Medical Genomics 2010 3:5
    Content type: Research article Published on:

  50. Abberant DNA methylation at CpG dinucleotides represents a common mechanism of transcriptional silencing in cancer. Since CpG methylation is a reversible event, tumor supressor genes that have undergone silenc...

    Authors: Jill C Rubinstein, Nam Tran, Shuangge Ma, Ruth Halaban and Michael Krauthammer
    Citation: BMC Medical Genomics 2010 3:4
    Content type: Research article Published on:
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BMC Medical Genomics

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