MicroRNA-486: a dual-function biomarker for diagnosis and tumor immune microenvironment characterization in non-small cell lung cancer

Yu, Jun; Shen, Yi; Xu, Yao; Feng, Zhengyang; Shen, Yuntian; Zhu, Yaqun; Huan, Jian; Peng, Qiliang

doi:10.1186/s12920-025-02158-9

Table 3 The main features of the enrolled studies regarding combination markers containing miR-486 in diagnosing NSCLC

From: MicroRNA-486: a dual-function biomarker for diagnosis and tumor immune microenvironment characterization in non-small cell lung cancer

Author	Year	Country	Ethnity	Case			Control		Combinations	Source	Methods	AUC	Sensitivity	Specificity
Author	Year	Country	Ethnity	No	Age	Stage	No	Age	Combinations	Source	Methods	AUC	Sensitivity	Specificity
Yu et al	2010	USA	Caucasian, African	36	68	I	36	67	miR-486, miR-21, miR-200b, miR-375	Sputum	qRT-PCR	0.896	0.82	0.92
Yu et al	2010	USA	Caucasian, African	64	67	I-IV	58	65	miR-486, miR-21, miR-200b, miR-376	Sputum	qRT-PCR	0.839	0.70	0.80
Bianchi et al	2011	Italy	Caucasian	25	NA	I-IV	39	NA	34-miRNA panel	Serum	qRT-PCR	0.920	0.69	0.84
Bianchi et al	2011	Italy	Caucasian	34	NA	I-IV	30	NA	34-miRNA panel	Serum	qRT-PCR	0.890	0.71	0.90
Shen et al	2011	USA	Caucasian, African	32	66	I-IV	33	65	miR-486, miR-21, miR-210	Plasma	qRT-PCR	0.855	0.75	0.85
Shen et al	2011	USA	Caucasian, African	76	68	I-IV	80	65	miR-486, miR-21, miR-210	Plasma	qRT-PCR	NA	0.76	0.85
Shen et al	2011	USA	Caucasian, African	58	68	I-IV	29	66	miR-486, miR-21, miR-210, miR-186	Plasma	qRT-PCR	0.926	0.86	0.97
Tai et al	2016	Japan	Asian	143	66	I-IV	49	66	20-miRNA panel	Serum	qRT-PCR	0.991	0.94	0.98
Tai et al	2016	Japan	Asian	110	65	I-IV	52	66	20-miRNA panel	Serum	qRT-PCR	0.975	0.89	0.98
Wang et al	2016	China	Asian	59	56	I-III	59	57	miR-486, miR-210	Plasma	qRT-PCR	0.892	0.83	0.78
Sromek et al	2017	Poland	Caucasian	61	63	I-IV	50	57	miR-486, miR-16, miR-205	Plasma	qRT-PCR	0.898	0.80	0.95
Yao et al	2019	China	Asian	389	66	I-IV	104	69	miR-486, miR-451, miR-194	Plasma	qRT-PCR	0.965	0.91	0.98
Liao et al	2020	USA	Caucasian, African	76	67	I-IV	72	66	miR-486, miR-21, miR-210	Plasma	qRT-PCR	0.850	0.75	0.83
Liu et al	2020	USA	Caucasian	32	NA	I-II	15	NA	miR-486, miR-21, miR-25, miR-155, miR-210	Serum	qRT-PCR	0.815	0.79	0.86
Liu et al	2020	USA	Caucasian	32	NA	III-IV	15	NA	miR-486, miR-21, miR-25, miR-155, miR-210	Serum	qRT-PCR	0.866	0.94	0.71
Wang et al	2020	China	Asian	82	54	I-IV	90	57	8-miRNA panel	Serum	qRT-PCR	0.966	0.91	0.93
Wu et al	2020	China	Asian	48	59	I-II	48	51	miR-486, miR-21, miR-141, miR-222, miR-146	Serum	qRT-PCR	0.960	0.86	0.93

AUC area under curve, NA not available
34-miRNA panel: miR-486, let-7a, let-7b, let-7 d, miR-103, miR-126, miR-133b, miR-139, miR-140, miR-142, miR-142, miR-148a, miR-148b, miR-17, miR-191, miR-22, miR-223, miR-26a, miR-26b, miR-28, miR-29a, miR-30b, miR-30c, miR-32, miR-328, miR-331, miR-342, miR-374, miR-376a, miR-432, miR-484, miR-566, miR-92a and miR-98; 20-miRNA panel: miR-486-5p, miR-451, miR-1290, miR-636, miR-30c, miR-22-3p, miR-19b, miR-20b, miR-93, miR-34b, miR-185, miR-126, miR-93, miR-1274, miR-142, miR-628, miR-486-3p, miR-425, miR-645, miR-24; 8-miRNA panel: miR-486-5p, miR-142-5p, miR-203a-5p, miR-409-3p, miR-223-3p, miR-150-5p, and miR-146a-5p

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