Table 2 Summary table of the value of miR-486 in the diagnosis of NSCLC

Sample types

 Serum

3

0.75 (0.67–0.82)

0.60 (0.53–0.66)

4 (3–7)

1.8 (1.5–2.2)

0.44 (0.32–0.60)

0.70 (0.62–0.78)

 Plasma

8

0.78 (0.73–0.83)

0.88 (0.74–0.95)

26 (9–72)

6.4 (2.8–14.4)

0.25 (0.19–0.33)

0.84 (0.81–0.87)

 Circulating

11

0.77 (0.73–0.81)

0.81 (0.67–0.90)

15 (6–36)

4.2 (2.2–8.0)

0.28 (0.21–0.37)

0.82 (0.78–0.85)

Ethnicity

 Asian

5

0.80 (0.73–0.85)

0.85 (0.59–0.96)

22 (4–109)

5.2 (1.6–17.1)

0.24 (0.15–0.38)

0.84 (0.80–0.87)

 Caucasian

3

0.74 (0.67–0.80)

0.75 (0.65–0.83)

16 (3–73)

5.2 (0.6–42.3)

0.30 (0.24–0.39)

0.82 (0.78–0.86)

 Mixed

10

0.71 (0.64–0.78)

0.73 (0.65–0.79)

7 (4–11)

2.6 (2.0–3.4)

0.39 (0.31–0.50)

0.76 (0.72–0.79)

Sample size

 Large sample size (≥ 100)

8

0.78 (0.70–0.85)

0.87 (0.73–0.95)

25 (8–79)

6.2 (2.7–14.3)

0.25 (0.17–0.37)

0.88 (0.84–0.90)

 Small sample size (< 100)

6

0.79 (0.71–0.85)

0.67 (0.58–0.75)

7 (5–12)

2.4 (1.9–3.0)

0.32 (0.24–0.43)

0.80 (0.76–0.83)

 Overall

14

0.78 (0.72–0.83)

0.81 (0.70–0.89)

15 (7–32)

4.1 (2.4–6.8)

0.27 (0.20–0.36)

0.85 (0.81–0.88)

 Outliers excluded

12

0.74 (0.70–0.78)

0.74 (0.66–0.81)

8 (5–13)

2.9 (2.1–3.9)

0.35 (0.29–0.42)

0.79 (0.75–0.83)

 Combination biomarkers

17

0.83 (0.79–0.87)

0.91 (0.87–0.94)

51 (25–100)

9.4 (5.9–14.8)

0.19 (0.14–0.24)

0.92 (0.90–0.94)