MicroRNA-486: a dual-function biomarker for diagnosis and tumor immune microenvironment characterization in non-small cell lung cancer

Table 1 The main features of the included studies for miR-486 in the diagnosis of NSCLC

Author	Year	Country	Ethnity	Case			Control		Source	Methods	AUC	Sensitivity	Specificity
Author	Year	Country	Ethnity	No	Age	Stage	No	Age	Source	Methods	AUC	Sensitivity	Specificity
Yu et al	2010	USA	Caucasian, African	36	68	I	36	67	Sputum	qRT-PCR	0.834	0.67	0.79
Yu et al	2010	USA	Caucasian, African	64	67	I-IV	58	65	Sputum	qRT-PCR	0.727	0.63	0.69
Shen et al	2011	USA	Caucasian, African	32	66	I-IV	33	65	Plasma	qRT-PCR	0.629	0.72	0.67
Shen et al	2011	USA	Caucasian, African	58	68	I-IV	29	66	Plasma	qRT-PCR	0.878	0.84	0.69
Mozzoni et al	2013	Italy	Caucasian	54	69	I-III	46	64	Plasma	qRT-PCR	0.857	0.70	0.89
Li et al	2015	China	Asian	11	59	I-III	11	55	Plasma	qRT-PCR	0.926	0.91	0.82
Wang et al	2016	China	Asian	59	56	I-III	59	57	Plasma	qRT-PCR	0.848	0.83	0.78
Leng et al	2017	USA	Caucasian, African	92	66	I-IV	88	66	Plasma	qRT-PCR	0.796	0.71	0.83
Sromek et al	2017	Poland	Caucasian	61	63	I-IV	50	57	Plasma	qRT-PCR	0.850	0.75	0.95
Mohamed et al	2018	Egypt	African	50	59	I-IV	50	58	Tissue	qRT-PCR	0.980	0.96	0.84
Yao et al	2019	China	Asian	389	66	I-IV	104	69	Plasma	qRT-PCR	0.957	0.86	0.99
Liu et al	2020	USA	Caucasian	64	NA	I-IV	15	NA	Serum	qRT-PCR	0.634	0.83	0.50
Wang et al	2020	China	Asian	82	54	I-IV	90	57	Serum	qRT-PCR	0.658	0.71	0.59
Wu et al	2020	China	Asian	48	59	I-II	48	51	Serum	qRT-PCR	0.697	0.77	0.66

ISSN: 1755-8794