Fig. 5
From: Dynamic clustering of genomics cohorts beyond race, ethnicity—and ancestry
Dynamic clusters across cancer types highlight clinical and functional associations. a Dynamic cluster 1 (C1) based on the COSMIC subset in LUAD (LUAD-COSMIC) shows statistically significant lower age cancer onset than that of the second cluster (C2; padj < 0.05). b C1 in LIHC-COSMIC includes samples with higher tumor grade compared to other clusters combined (padj < 0.05). Clusters C5 and C8 include no Grade 4 samples. c C1 shows more advanced tumor stage samples in LIHC-HFI compared to C2 (padj < 0.05). d Genes significantly expressed (FDR < 0.05) in opposite directions among clusters of BRCA-COSMIC, BRCA-HFI and LIHC-COSMIC highlight potential functional roles associated with different clusters. e Gene programs with known association to cancer are collectively expressed in different magnitudes and directions between dynamic clusters across cancer types and settings