Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study

BMC Medical Genomics

Table 4 Mendelian randomization estimates between IBD and sepsis (28-day death in critical care)

Exposures	Outcomes	No. of SNPs	IVW		MR-Egger		Weighted median		Simple median		MR-PRESSO
Exposures	Outcomes	No. of SNPs	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
CD	All	120	1.240 (1.096–1.402)	6.09 × 10^–4	1.140 (0.822–1.58)	0.432	1.230 (1.017–1.488)	0.033	1.241 (1.027–1.501)	0.025	1.240 (1.104–1.392)	4.12 × 10^–4
	Remove	98	1.246 (1.09–1.423)	1.23 × 10^–3	1.071 (0.765–1.501)	0.688	1.241 (1.012–1.521)	0.037	1.246 (1.015–1.53)	0.035	1.246 (1.1–1.411)	8.24 × 10^–4
UC	All	86	1.101 (0.948–1.279)	0.207	0.797 (0.556–1.144)	0.218	1.021 (0.818–1.275)	0.851	1.152 (0.919–1.443)	0.219	1.101 (0.962–1.26)	0.164
	Remove	71	1.075 (0.914–1.264)	0.384	0.813 (0.554–1.192)	0.288	1.017 (0.802–1.291)	0.887	1.090 (0.853–1.393)	0.490	1.075 (0.925–1.249)	0.349

“All” represents analyses with all selected SNPs, “Removed” represents analyses after removing SNPs associated with relevant confounders or sepsis. Abbreviations: CD Crohn's disease, CI Confidence interval, IBD Inflammatory bowel diseases, IVW Inverse-variance weighted, MR-PRESSO MR Pleiotropy Summary, OR Odds ratio, SNPs Single nucleotide polymorphisms, UC Ulcerative colitis

ISSN: 1755-8794