Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study

BMC Medical Genomics

Table 1 Description of the IVs associated with IBD used in the TSMR study

Risk factor	SNPs used in MR study (Sepsis/critical care sepsis/28-day death in critical care sepsis)	SNPs after removing SNPs associated with confounders (Sepsis/critical care sepsis/28-day death in critical care sepsis)	Proxy SNP	Sample size	Population	GWAS	Year	PMID
CD	120/120/120	98/98/98	8	20,883	European	Liu et al	2015	26,192,919
UC	86/86/86	71/71/71	8	27,432	European	Liu et al	2015	26,192,919

Abbreviations: CD Crohn's disease, GWAS Genome-wide association study, IBD Inflammatory bowel disease, IVs instrumental variables, PMID PubMed unique identifier, SNPs Single-nucleotide polymorphisms, TSMR Two-sample Mendelian randomization, UC Ulcerative colitis

ISSN: 1755-8794