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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study

Fig. 4

Functional enrichment analysis of the relevant genes according to SNPs. (A)Bar plots showing the top 20 GO terms. (B)Bar plots showing the top 15 enriched KEGG and HALLMARK pathways. (C) A Venn diagram was constructed to illustrate the overlapping SNPs between the documented IBD genetic risk loci associated with sepsis (Left ellipse) and the IVs for CD in our TSMR analysis (Right ellipse). Among the 98 IVs from CD, one IVs (rs7236492) were common to the 8 IBD risk loci reported previously. Abbreviations: CD, Crohn's disease; IBD, Inflammatory bowel diseases; IVs, instrumental variables; TSMR, Two-sample Mendelian randomization; SNPs, Single nucleotide polymorphisms

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BMC Medical Genomics

ISSN: 1755-8794

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