Fig. 2

Overview of the MR results before (A) and after (B) removing the SNPs potentially associated with confounders. The results were mainly analyzed by IVW method. The genetic susceptibility of CD was significantly causally associated with sepsis (28-day death in critical care). Abbreviations: CD, Crohn's disease; IBD, Inflammatory bowel diseases; MR, Mendelian randomization; SNPs, Single nucleotide polymorphisms; UC, Ulcerative colitis