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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study

Fig. 1

MR is a wide applied method which determines genetic variation as IVs to elucidate causality between exposure (IBD, including CD and UC) and outcome (sepsis, critical care sepsis (critical care), and sepsis (28-day death in critical care)). Three assumptions should be satisfied beforehand: 1. the genetic variants (i.e. SNPs) should be firmly linked to IBD; 2. the genetic variants can not be affected by any confounding factors; 3. IVs influence the risk of sepsis exclusively via the pathway involving IBD. Abbreviations: CD, Crohn's disease; IBD, Inflammatory bowel diseases; IVs, instrumental variables; MR, Mendelian randomization; SNPs, Single nucleotide polymorphisms; UC, Ulcerative colitis

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BMC Medical Genomics

ISSN: 1755-8794

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