Comprehensive chromosomal abnormality detection: integrating CNV-Seq with traditional karyotyping in prenatal diagnostics

Table 1 Patient characteristics

	AMA (N = 401)	HR-MSS (N = 388)	USM (N = 105)	Others (N = 57)	HR-NIPT (N = 40)	Mixed¹ (N = 10)	Total (N = 1001)
Age
Mean	39.2	31.3	31.0	31.0	32.3	36.9	34.4
Range	24–49	20–38	20–40	20–37	24–40	25–42	20–49
Gestational age wk^+ d
Mean	19^+ 4	20	20^+ 6	19^+ 3	20^+ 3	19^+ 3	19^+ 6
Range	18–24^+ 4	18–24^+ 5	18–24^+ 4	18–22^+ 3	18–24	18^+ 4– 21^+ 1	18–24^+ 5

AMA, advanced maternal age; HR-MSS, high-risk maternal serum screening; USM, ultrasound soft marker; HR-NIPT, high-risk non-invasive prenatal testing.
¹This group consisted of patients with mixed indications, including AMA, HRMSS, USM, HR-NIPT, inheritable risk of a single gene disease and prior risk of an abnormal pregnancy outcome.

ISSN: 1755-8794