Table 1 Characteristics of the studies included in the review. Age is presented as the mean and standard deviation or range (minimum to maximum). Genotype and allele frequencies are presented as counts and percentages
From: The frequency of the ACTN3 polymorphism in Brazil: a systematic review and meta-analysis
Study | Sample | Age (years) | RR | RX | XX | R | X |
|---|---|---|---|---|---|---|---|
A. C. Silva et al. 2024 [22] | 71 | 66.3 ± 6.2 | 25 (35.2) | 37 (52.1) | 9 (12.7) | 87 (61.3) | 55 (38.7) |
Albuquerque-Neto et al. 2020 [23] | 990 | 18 to 20 | 326 (32.9) | 452 (45.7) | 212 (21.4) | 1104 (55.8) | 876 (44.2) |
Albuquerque-Neto et al. 2024 [20] | 573 | 20 to 30 | 197 (34.4) | 261 (45.5) | 115 (20.1) | 655 (57.2) | 491 (42.8) |
Almeida et al. 2022 [24] | 83 | 25.9 ± 4.9 | 34 (41) | 38 (45.8) | 11 (13.3) | 106 (63.9) | 60 (36.1) |
Aranalde et al. 2016 [25] | 60 | 44.1 ± 11.3 | 24 (40) | 31 (51.7) | 5 (8.3) | 79 (65.8) | 41 (34.2) |
Arejano et al. 2024 [26] | 78 | 18 to 59 | 24 (30.8) | 31 (39.7) | 23 (29.5) | 79 (50.6) | 77 (49.4) |
Belli et al. 2017 [27] | 20 | 40.75 | 7 (35) | 9 (45) | 4 (20) | 23 (57.5) | 17 (42.5) |
Bernardez-Pereira et al. 2014 [28] | 463 | 58 ± 14 | 178 (38.4) | 213 (46) | 72 (15.6) | 569 (61.4) | 357 (38.6) |
Bottura et al. 2019 [29] | 61 | 29.2 ± 4.7 | 21 (34.4) | 32 (52.5) | 8 (13.1) | 74 (60.7) | 48 (39.3) |
Coelho et al. 2018 [30] | 453 | 17.6 ± 1 | 194 (42.8) | 205 (45.3) | 54 (11.9) | 593 (65.5) | 313 (34.5) |
Corrêa et al. 2021 [31] | 30 | 23 ± 5.2 | 11 (36.7) | 13 (43.3) | 6 (20) | 35 (58.3) | 25 (41.7) |
Costa et al. 2020 [32] | 400 | 4 to 13 | 155 (38.8) | 161 (40.3) | 84 (21) | 471 (58.9) | 329 (41.1) |
Cunha-Montenegro et al. 2012 [33] | 82 | 7 to 17 | 29 (35.4) | 42 (51.2) | 11 (13.4) | 100 (61) | 64 (39) |
Dionísio et al. 2017 [34] | 175 | 14 to 20 | 56 (32) | 89 (50.9) | 30 (17.1) | 201 (57.4) | 149 (42.6) |
G. Lima et al. 2023 [19] | 292 | - | 113 (38.7) | 127 (43.5) | 52 (17.8) | 353 (60.4) | 231 (39.6) |
Gentil et al. 2011 [35] | 141 | 22.2 ± 3.4 | 50 (35.5) | 66 (46.8) | 25 (17.7) | 166 (58.9) | 116 (41.1) |
Guilherme et al. 2018 [21] | 1616 | 27.6 ± 10.5 | 550 (34) | 745 (46.1) | 321 (19.9) | 1845 (57.1) | 1387 (42.9) |
Guilherme et al. 2024 [36] | 203 | - | 48 (23.6) | 101 (49.8) | 54 (26.6) | 197 (48.5) | 209 (51.5) |
Henrique et al. 2022 [4] | 347 | 71 ± 6.28 | 110 (31.7) | 148 (42.7) | 89 (25.6) | 368 (53) | 326 (47) |
Hernández-Mosqueira et al. 2022 [18] | 59 | - | 17 (28.8) | 28 (47.5) | 14 (23.7) | 62 (52.5) | 56 (47.5) |
João et al. 2015 [37] | 59 | - | 16 (27.1) | 29 (49.2) | 14 (23.7) | 61 (51.7) | 57 (48.3) |
Luciano et al. 2016 [38] | 215 | 10 to 35 | 73 (34) | 105 (48.8) | 37 (17.2) | 251 (58.4) | 179 (41.6) |
M. S. M. Silva et al. 2015 [39] | 205 | 25 ± 4 | 75 (36.6) | 97 (47.3) | 33 (16.1) | 247 (60.2) | 163 (39.8) |
Machado et al. 2022 [40] | 141 | 68.3 ± 6.2 | 65 (46.1) | 63 (44.7) | 13 (9.2) | 193 (68.4) | 89 (31.6) |
Marques et al. 2024 [41] | 344 | 23.9 ± 5.4 | 123 (35.8) | 165 (48) | 56 (16.3) | 411 (59.7) | 277 (40.3) |
Moraes et al. 2018 [42] | 87 | 60.6 ± 5.7 | 29 (33.3) | 43 (49.4) | 15 (17.2) | 101 (58) | 73 (42) |
Oliveira et al. 2020 [43] | 63 | 28 ± 5.8 | 18 (28.6) | 34 (54) | 11 (17.5) | 70 (55.6) | 56 (44.4) |
Pasqua et al. 2015 [44] | 150 | 25.2 ± 4 | 51 (34) | 57 (38) | 42 (28) | 159 (53) | 141 (47) |
Pereira et al. 2013 [45] | 139 | 65.5 ± 8.2 | 54 (38.8) | 52 (37.4) | 33 (23.7) | 160 (57.6) | 118 (42.4) |
Pimenta et al. 2012 [46] | 37 | 24.4 ± 3.5 | 15 (40.5) | 13 (35.1) | 9 (24.3) | 43 (58.1) | 31 (41.9) |
Pimenta et al. 2013 [47] | 200 | 24.4 ± 2 | 82 (41) | 96 (48) | 22 (11) | 260 (65) | 140 (35) |
R. M. Lima et al. 2011 [48] | 234 | 66.7 ± 5.5 | 78 (33.3) | 119 (50.9) | 37 (15.8) | 275 (58.8) | 193 (41.2) |
Ribas et al. 2017 [49] | 37 | 26.5 ± 5.7 | 17 (45.9) | 14 (37.8) | 6 (16.2) | 48 (64.9) | 26 (35.1) |
Ribas et al. 2020 [50] | 19 | 41.2 ± 6.1 | 3 (15.8) | 11 (57.9) | 5 (26.3) | 17 (44.7) | 21 (55.3) |
Ribas et al. 2023 [51] | 22 | 35.9 ± 6.5 | 5 (22.7) | 12 (54.5) | 5 (22.7) | 22 (50) | 22 (50) |
Ribeiro et al. 2014 [52] | 123 | 15 to 67 | 45 (36.6) | 57 (46.3) | 21 (17.1) | 147 (59.8) | 99 (40.2) |
Rodrigues et al. 2022 [53] | 70 | 50 to 70 | 22 (31.4) | 38 (54.3) | 10 (14.3) | 82 (58.6) | 58 (41.4) |
Rosa et al. 2022 [54] | 36 | 16.4 ± 1.2 | 14 (38.9) | 19 (52.8) | 3 (8.3) | 47 (65.3) | 25 (34.7) |
Santos et al. 2024 [55] | 97 | 27.2 ± 4.5 | 42 (43.3) | 47 (48.5) | 8 (8.2) | 131 (67.5) | 63 (32.5) |
Sierra et al. 2019 [56] | 81 | 38.3 ± 1.7 | 22 (27.2) | 43 (53.1) | 16 (19.8) | 87 (53.7) | 75 (46.3) |
Silvino et al. 2025 [57] | 165 | 16.4 ± 0.7 | 53 (32.1) | 84 (50.9) | 28 (17.0) | 190 (57.6) | 140 (42.4) |
Wajchenberg et al. 2013 [58] | 25 | 30.1 ± 13.5 | 6 (24) | 11 (44) | 8 (32) | 23 (46) | 27 (54) |