Table 2 SNPs showing association with ex-vivo response of nonchemotherapy drugs as group at geome-wide significance levels in the multivariate analysis
CHR | BP | Variant (Gene) | Allele | Shift/Polyphen 2 | MAF | Pval | Central traits | Drug group |
|---|---|---|---|---|---|---|---|---|
11 | 76507403 | rs11236938-G/A (TSKU) | S (Ser) > N (Asn) | Tolerated/ benign | 0.03 | 3.8 × 10− 11 | Tamoxifen, BI.2536, Belinostat | Non chemotherapy |
2 | 27438615 | rs11556165-G/C(ATRAID) | D (Asp) > H (His) | Tolerated/NA | 0.04 | 3.98 × 10− 9 | Belinostat, Fingolimod, Alvocidib | Non chemotherapy |
1 | 184764824 | rs35704242-C/T (NIBAN1) | D (Asp) > N (Asn) | Tolerated/NA | 0.04 | 2.51 × 10− 8 | BI.2536, Gefitinib, Belinostat | Non chemotherapy |