Table 4 DMGs overlapping with DEGs in severe vs mild COVID-19 as identified in the datasets of Gómez-Carballa et al. and Rombauts et al. [62, 63]. Negative values represent relative hypomethylation in the case of Methylation difference (%) and decreased relative gene expression in the case of analyses of the Gómez-Carballa et al. and Rombauts et al. datasets. Methylation difference and q-value represent data derived from our original dataset. Log2 Fold Change and Padj represent data from comparative datasets. Rows in boldface indicate genes in which the direction of differential gene expression is concordant with what is expected from the methylation difference noted in our data
Gene | Methylation difference (%) | q-value | Overlapping dataset | Log2 Fold Change | Padj |
|---|---|---|---|---|---|
CD96 | 11.2 | 1.50E-17 | Gómez-Carballa | −1.25 | 8.56E-04 |
IRF4 | 12.4 | 1.18E-20 | Gómez-Carballa | −0.90 | 8.79E-04 |
LCK | 15.1 | 5.13E-18 | Gómez-Carballa | −0.96 | 1.50E-03 |
PTPN22 | 24.6 | 5.30E-17 | Gómez-Carballa | −0.74 | 7.69E-03 |
ITGAL | 16.6 | 2.10E-16 | Gómez-Carballa | −0.62 | 7.69E-03 |
CD59 | 10.1 | 9.74E-23 | Gómez-Carballa | 0.64 | 7.69E-03 |
CD8A | 17.3 | 1.50E-21 | Gómez-Carballa | −0.98 | 9.25E-03 |
IRAK2 | 12.5 | 3.40E-27 | Gómez-Carballa | 0.82 | 3.87E-02 |
TLR5 | −16.7 | 2.71E-18 | Gómez-Carballa | 0.72 | 4.63E-05 |
IL1R2 | −15.9 | 2.49E-16 | Gómez-Carballa | 1.85 | 1.06E-04 |
IKZF1 | −14.1 | 5.54E-16 | Gómez-Carballa | 0.58 | 2.45E-03 |
CD6 | −14.6 | 8.45E-16 | Gómez-Carballa | −1.17 | 7.96E-03 |
TBX21 | −17.4 | 1.67E-22 | Gómez-Carballa | −1.40 | 9.55E-03 |
NOTCH1 | −20.2 | 2.23E-16 | Gómez-Carballa | 0.63 | 1.17E-02 |
CD3E | −14.7 | 4.09E-19 | Gómez-Carballa | −1.79 | 1.24E-02 |
NFKBIA | −15.8 | 1.02E-16 | Gómez-Carballa | −2.19 | 1.70E-02 |
ICOS | −21.7 | 4.62E-20 | Gómez-Carballa | −2.69 | 2.51E-02 |
GP1BB | −23.7 | 5.95E-19 | Gómez-Carballa | 0.57 | 3.74E-02 |
HLA-DPA1 | −20.1 | 1.10E-16 | Gómez-Carballa | −1.24 | 2.00E-03 |
|  |  |  | Rombauts | −0.83 | 5.79E-03 |
CEBPE | 27 | 3.50E-17 | Rombauts | 0.32 | 3.47E-02 |
DPM2 | 17.9 | 1.32E-20 | Rombauts | −0.26 | 1.89E-02 |
LRG1 | 30.3 | 3.61E-23 | Rombauts | 0.50 | 4.59E-02 |
PSMG4 | 15.5 | 1.10E-21 | Rombauts | −0.24 | 4.13E-02 |
SEPT1 | 22.5 | 2.67E-19 | Rombauts | −0.58 | 1.11E-02 |
ALYREF | −12.3 | 7.45E-17 | Rombauts | −0.33 | 4.79E-02 |
EEF2 | −33.7 | 7.92E-24 | Rombauts | −0.34 | 2.24E-02 |
HHEX | −12.6 | 4.84E-20 | Rombauts | 0.39 | 3.59E-02 |
KRT39 | −10.1 | 7.67E-20 | Rombauts | 0.26 | 3.04E-02 |