Fig. 6

Differential regulation of immune cells and the response, as well as differential response to foreign pathogens are present in severe vs mild COVID-19. Utilizing the overlapping genes identified in our original dataset and the datasets of Gómez-Carballa et al. [62] and Rombauts et al. [63], the top 25 most significantly enriched GO Biological Processes, KEGG Pathways, and Reactome Gene Sets are displayed from relatively (A) hypo- and (B) hypermethylated in severe vs mild COVID-19. Ontologies are listed along the y-axis. -Log P values are displayed along the x-axis