Fig. 4

Ribbon representations of PTPRQ protein structure predictions using AlphaFold2 and rigid docking experiments. A, D, G PTPRQ wild type, c.6453+2dup and c.6602+81_6738+394delinsTTTATAAAATG phosphatase domains. B, E, H Close up of the active site of the PTPRQ phosphatase domains. C, F, I rigid docking results. For the wild type structure (C) the result with the highest affinity according to autodock vina was used to illustrate ligand binding. For the variants (F & I) docking results were superimposed. Distinct colors mark various segments of the active site: Cyan for the PTP-loop, magenta for the Q-loop, yellow for the WPE-loop, and orange for Arg2790 and Glu2785