Table 3 Summary risk estimates for association of ITPKC rs2290692, rs7251246 and rs10420685 polymorphisms with KD risk
Subgroup | Genetic Model | Type of Model | Heterogeneity | Odds Ratio | Publication Bias | |||||
|---|---|---|---|---|---|---|---|---|---|---|
I2(%) | PH | OR | 95% CI | Ztest | POR | PBeggs | PEggers | |||
rs2290692 | C vs. G | Random | 75.21 | 0.007 | 1.128 | 0.857–1.483 | 0.859 | 0.390 | 0.734 | 0.729 |
|  | CC vs. GG | Random | 76.44 | 0.005 | 1.226 | 699 − 2.150 | 0.711 | 0.477 | 0.308 | 0.621 |
|  | CG vs. GG | Fixed | 0.00 | 0.621 | 1.254 | 1.012–1.555 | 2.069 | 0.039 | 1.000 | 0.494 |
|  | CC + CG vs. GG | Fixed | 32.39 | 0.218 | 1.276 | 1.043–1.560 | 2.369 | 0.009 | 1.000 | 0.900 |
|  | CC vs. CG + GG | Random | 78.01 | 0.003 | 1.064 | 0.653–1.734 | 0.249 | 0.804 | 0.734 | 0.616 |
rs7251246 | C vs. G | Fixed | 0.00 | 0.833 | 1.058 | 0.910–1.229 | 0.731 | 0.465 | NA | NA |
|  | CC vs. GG | Fixed | 0.00 | 0.837 | 1.141 | 0.838–1.555 | 0.839 | 0.402 | NA | NA |
|  | CG vs. GG | Random | 0.00 | 0.597 | 1.133 | 0.871–1.473 | 0.933 | 0.351 | NA | NA |
|  | CC + CG vs. GG | Random | 0.00 | 0.752 | 1.132 | 0.882–1.453 | 0.976 | 0.329 | NA | NA |
|  | CC vs. CG + GG | Fixed | 0.00 | 0.535 | 1.029 | 0.804–1.318 | 0.228 | 0.820 | NA | NA |
rs10420685 | C vs. G | Random | 81.46 | 0.020 | 0.807 | 0.534–1.221 | -1.013 | 0.311 | NA | NA |
|  | CC vs. GG | Fixed | 0.00 | 0.864 | 0.950 | 0.605–1.491 | -0.224 | 0.823 | NA | NA |
|  | CG vs. GG | Fixed | 0.00 | 0.708 | 1.053 | 0.839–1.322 | 0.446 | 0.656 | NA | NA |
|  | CC + CG vs. GG | Fixed | 0.00 | 0.728 | 1.036 | 0.834–1.287 | 0.318 | 0.750 | NA | NA |
|  | CC vs. CG + GG | Fixed | 0.00 | 0.929 | 0.925 | 0.595–1.438 | -0.345 | 0.730 | NA | NA |