A comprehensive integration of data on the association of ITPKC polymorphisms with susceptibility to Kawasaki disease: a meta-analysis

Habibi, Atefeh; Talebi, Hanieh; Bahrami, Reza; Golshan-Tafti, Mohammad; Shahbazi, Amirhossein; Dastgheib, Seyed Alireza; Tahooni, Azadeh; Vafapour, Maryam; Rashnavadi, Heewa; Pourkazemi, Melina; Yeganegi, Maryam; Sheikhpour, Elnaz; Neamatzadeh, Hossein

doi:10.1186/s12920-025-02121-8

Table 2 Summary risk estimates for association of ITPKC rs28493229 polymorphism with KD risk

From: A comprehensive integration of data on the association of ITPKC polymorphisms with susceptibility to Kawasaki disease: a meta-analysis

Subgroup	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
Subgroup	Genetic Model	Type of Model	I²(%)	P_H	OR	95% CI	Z_test	P_OR	P_Beggs	P_Eggers
Overall	C vs. G	Random	59.46	0.008	1.349	1.128–1.615	3.276	0.001	0.283	0.197
	CC vs. GG	Fixed	3.39	0.404	2.025	1.399–2.929	3.744	≤ 0.001	1.000	0.314
	CG vs. GG	Random	59.78	0.008	1.375	1.125–1.681	3.108	0.002	0.210	0.236
	CC + CG vs. GG	Random	62.81	0.004	1.387	1.130–1.703	3.132	0.002	0.152	0.205
	CC vs. CG + GG	Fixed	0.00	0.461	1.767	1.224–2.550	3.042	0.002	0.710	0.445
Asians	C vs. G	Random	61.45	0.008	1.361	1.139–1.627	3.392	0.001	0.348	0.316
	CC vs. GG	Fixed	3.39	0.404	2.025	1.399–2.929	3.744	≤ 0.001	1.000	0.314
	CG vs. GG	Random	61.62	0.008	1.390	1.139–1.697	3.238	0.001	0.348	0.384
	CC + CG vs. GG	Random	64.65	0.004	1.403	1.145–1.719	3.264	0.001	0.251	0.328
	CC vs. CG + GG	Fixed	0.00	0.461	1.767	1.224–2.550	3.042	0.002	0.710	0.445
Chinese	C vs. G	Fixed	64.21	0.025	1.184	0.897–1.563	1.191	0.234	0.806	0.885
	CC vs. GG	Fixed	0.00	0.867	0.972	0.421–2.245	-0.066	0.947	1.000	0.850
	CG vs. GG	Fixed	64.29	0.024	1.224	0.908–1.652	1.326	0.185	0.806	0.882
	CC + CG vs. GG	Fixed	65.10	0.022	1.212	0.900-1.631	1.265	0.206	0.806	0.885
	CC vs. CG + GG	Fixed	0.00	0.872	0.960	0.416–2.215	-0.096	0.924	1.000	0.786
Source of Controls
PB	C vs. G	Random	61.46	0.075	1.103	0.591–2.060	0.308	0.758	1.000	0.642
	CC vs. GG	Random	60.77	0.110	1.326	0.073–5.977	0.190	0.849	NA	NA
	CG vs. GG	Fixed	34.06	0.219	1.206	0.855–1.701	1.067	0.286	1.000	0.506
	CC + CG vs. GG	Random	51.97	0.125	1.133	0.634–2.024	0.422	0.673	1.000	0.587
	CC vs. CG + GG	Random	58.45	0.121	1.005	0.173–5.829	0.006	0.995	NA	NA
HB	C vs. G	Fixed	45.00	0.162	1.541	1.366–1.739	7.024	≤ 0.001	0.296	0.142
	CC vs. GG	Fixed	39.16	0.193	2.214	1.482–3.308	3.879	≤ 0.001	1.000	0.671
	CG vs. GG	Random	60.38	0.080	1.544	1.218–1.956	3.594	≤ 0.001	0.296	0.421
	CC + CG vs. GG	Random	59.82	0.083	1.578	1.256–1.982	3.913	≤ 0.001	0.296	0.280
	CC vs. CG + GG	Fixed	41.70	0.180	1.888	1.267–2.812	3.126	0.002	1.000	0.759
Genotyping Methods
TaqMan	C vs. G	Fixed	42.31	0.158	1.493	1.308–1.705	5.928	≤ 0.001	0.734	0.441
	CC vs. GG	Fixed	0.00	0.596	1.751	1.073–2.857	2.243	0.025	0.734	0.897
	CG vs. GG	Random	50.90	0.106	1.500	1.190–1.891	3.435	0.001	0.734	0.295
	CC + CG vs. GG	Random	55.38	0.081	1.505	1.185–1.912	3.354	0.001	0.734	0.357
	CC vs. CG + GG	Fixed	0.00	0.661	1.476	0.908-2.400	1.571	0.116	0.734	0.942
Sequencing	C vs. G	Fixed	40.66	0.185	1.606	1.349–1.911	5.337	≤ 0.001	1.000	0.833
	CC vs. GG	Fixed	0.00	0.704	3.248	1.719–6.136	3.629	≤ 0.001	NA	NA
	CG vs. GG	Random	52.74	0.120	1.641	1.053–2.557	2.189	0.029	1.000	0.308
	CC + CG vs. GG	Fixed	44.85	0.163	1.656	1.357–2.021	4.967	≤ 0.001	1.000	0.807
	CC vs. CG + GG	Fixed	0.00	0.722	2.874	1.528–5.408	3.274	0.001	NA	NA

Abbreviations: I² - Heterogeneity statistic, P_H - P-value for heterogeneity, OR - Odds Ratio, CI - Confidence Interval, Z_test - Z-test statistic, P_OR - P-value for overall result, PB - Population-Based, HB - Hospital-Based, NA - Not Applicable

Back to article page

ISSN: 1755-8794

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Medical Genomics

Contact us