A comprehensive integration of data on the association of ITPKC polymorphisms with susceptibility to Kawasaki disease: a meta-analysis

Habibi, Atefeh; Talebi, Hanieh; Bahrami, Reza; Golshan-Tafti, Mohammad; Shahbazi, Amirhossein; Dastgheib, Seyed Alireza; Tahooni, Azadeh; Vafapour, Maryam; Rashnavadi, Heewa; Pourkazemi, Melina; Yeganegi, Maryam; Sheikhpour, Elnaz; Neamatzadeh, Hossein

doi:10.1186/s12920-025-02121-8

Table 1 Characteristics of studies included in this meta-analysis

From: A comprehensive integration of data on the association of ITPKC polymorphisms with susceptibility to Kawasaki disease: a meta-analysis

Author/Year	Country (Ethnicity)	SOC	Genotyping Methods	Case/Control	KD Cases					Controls					MAFs	HWE	NOS
Author/Year	Country (Ethnicity)	SOC	Genotyping Methods	Case/Control	Genotypes			Allele		Genotypes			Allele		MAFs	HWE	NOS
rs28493229					GG	GC	CC	G	C	GG	GC	CC	G	C
Onouchi 2008	Japan(Asian)	PB	TaqMan	637/1034	376	234	27	986	288	756	249	29	1761	307	0.148	0.126	8
Chi 2010	China(Asian)	NS	TaqMan	385/1158	323	61	1	707	63	1008	147	3	2163	153	0.066	0.327	8
Lin 2011	China(Asian)	NS	Sequencing	280/492	236	43	1	515	45	454	37	1	945	39	0.040	0.787	8
Kuo 2011	China(Asian)	PB	TaqMan	334/1131	282	50	2	614	54	981	142	8	2104	158	0.070	0.256	8
Peng 2012	China(Asian)	HB	PCR-RFLP	223/318	195	27	1	417	29	274	40	4	588	48	0.075	0.078	7
Onouchi 2013	Japan(Asian)	PB	Sequencing	546/938	330	191	25	851	241	662	261	15	1585	291	0.155	0.059	8
Yan 2013	China(Asian)	HB	TaqMan	358/815	315	40	3	670	46	703	107	5	1513	117	0.072	0.673	7
Natividad 2013	Australia(Caucasian)	HB	Sequencing	17/26	16	1	0	33	1	22	4	0	48	4	0.077	0.670	6
Kim 2018	Korea(Asian)	HB	TaqMan	299/210	231	64	4	526	72	178	32	0	388	32	0.076	0.232	7
Bhattarai 2021	India(Asian)	HB	PCR-RFLP	50/50	39	11	0	89	11	42	8	0	92	8	0.080	0.538	6
rs2290692					GG	GC	CC	G	C	GG	GC	CC	G	C
Kuo 2011	China(Asian)	PB	TaqMan	373/551	73	194	106	340	406	122	275	154	519	583	0.529	0.970	8
Peng 2012	China(Asian)	HB	PCR-RFLP	223/318	54	105	64	213	233	116	150	52	382	254	0.399	0.764	7
Kim 2018	Korea(Asian)	HB	TaqMan	299/210	89	143	67	321	277	65	97	48	227	193	0.460	0.309	7
Bhattarai 2021	India(Asian)	HB	PCR-RFLP	50/50	19	25	6	63	37	20	16	14	56	44	0.440	0.013	6
rs7251246					TT	TC	CC	T	C	TT	TC	CC	T	C
Kuo 2011	China(Asian)	PB	TaqMan	374/558	74	197	103	345	403	125	277	156	527	589	0.528	0.922	8
Liu 2023	China(Asian)	HB	SNaPshot	221/262	64	114	43	242	200	80	137	45	297	227	0.433	0.294	7
rs10420685					AA	AG	GG	A	G	AA	AG	GG	A	G
Kuo 2011	China(Asian)	PB	TaqMan	372/529	233	123	16	589	155	332	172	25	836	222	0.210	0.654	8
Kim 2018	Korea(Asian)	HB	TaqMan	299/210	156	116	27	428	170	114	76	20	304	116	0.276	0.169	7

Abbreviations: SOC - source of control; PB - population-based; HB - hospital-based; NS - not stated; PCR - polymerase chain reaction; PCR-RFLP - polymerase chain reaction-restriction fragment length polymorphism; MAF - minor allele frequency; HWE - Hardy-Weinberg equilibrium; NOS - Newcastle-Ottawa Scale

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ISSN: 1755-8794

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