Fig. 4

Clonal evolution in MM. A Clonal evolution of patient 189. Fishplot showing dynamic clonal evolution from BM-PCs to CPCs in patient 189. B Clonal evolution of patient 190. Fishplot showing dynamic clonal evolution from BM-PCs to CPCs in patient 190. C Clonal evolution of patient 193. Fishplot showing dynamic clonal evolution of patient 193 when disease progressed from the initial diagnosis. D Clonal evolution of patient 209. Fishplot showing dynamic clonal evolution of patient 209 when disease progressed from the remission phase. “*” SMGs, “^#” Cancer Gene Census (CGC) genes, “⁺” novel recurrent mutated genes identified in NDMM patients, “⁺⁺” novel recurrent mutated genes identified in RRMM patients, CBD C: cyclophosphamide; B: bortezomib; D: dexamethasone, VP16 etoposide, KPD K: carfilzomib; P: pomalidomide; D: dexamethasone, + positive,—negative, NA not available