Fig. 2

Recurrent mutated genes in NDMM. A Waterfall of NDMM patients’ gene mutations. All genes are divided into three groups, genes identified as SMGs by MutsigCV (SMG), previously reported SMGs (Public SMG) and some novel mutant genes (Novel). In the third group, six genes also appear in the validation cohort (cohort 1A, n = 77) at a higher frequency (> 5%) are marked with an asterisk. Related clinical characteristics of all patients are shown at the top, including sex, age at diagnosis, DS stage, ISS stage, R-ISS stage and sum of FISH results, which include t(4;14), t(14;16) and 17p-. DS Durie-Salmon, ISS International Staging System, R-ISS Revised International Staging System, FISH fluorescence in situ hybridization, SMG significantly mutated gene. B Frequency comparison of SMGs between cohort 1a and MMRF-COMMPASS. C NFKBIA somatic mutation sites in cohort 1a