Association of CYP19 gene SNPs (rs7176005 and rs6493497) with polycystic ovary syndrome susceptibility in Northern Chinese women

Table 2 Correlation of CYP19 gene rs7176005 C/T SNP and rs6493497 G/A SNP to susceptibility of PCOS

Locus	Genotype	Control (n = 340)	PCOS (n = 340)	P^a	OR(95%CI)^b	P^c	adjusted OR(95%CI)^d
rs7176005
	CC	178(52.4)	223(65.6)
	CT	129(37.9)	110(32.4)	0.019	0.681(0.493–0.939)	0.014	0.650(0.460–0.917)
	TT	33(9.7)	7(2.0)	0.000	0.169(0.073–0.392)	0.000	0.158(0.066–0.376)
	CT + TT	162(47.6)	117(34.4)	0.000	0.576(0.423–0.785)	0.000	0.545(0.391–0.759)
	C allele	485(71.3)	556(81.8)
	T allele	195(28.7)	124(18.2)	0.000	0.555(0.429–0.716)
rs6493497
	GG	178(52.4)	223(65.6)
	GA	129(37.9)	110(32.4)	0.019	0.681(0.493–0.939)	0.014	0.650(0.460–0.917)
	AA	33(9.7)	7(2.0)	0.000	0.169(0.073–0.392)	0.000	0.158(0.066–0.376)
	GA + AA	162(47.6)	117(34.4)	0.000	0.576(0.423–0.785)	0.000	0.545(0.391–0.759)
	G allele	485(71.3)	556(81.8)
	A allele	195(28.7)	124(18.2)	0.000	0.555(0.429–0.716)

p-Value < 0.05 is considered as significant
OR,odds ratio; CI,confidence interval
a, Two-sided χ² test; b, Unconditional logistic regression models; c, Two-sidedχ² test with the adjustment for age, BMI; d, Unconditional logistic regression models with the adjustment for age, BMI

ISSN: 1755-8794