Fig. 4
From: USP2 reversed cisplatin resistance through p53-mediated ferroptosis in NSCLC
USP2 promoted ferroptosis through the nuclear transfer of p53. (A-C) Western blotting was utilized for measuring p53 protein, GPX4, SLC7A11, TFRC and ACSL4 protein expression after USP2 overexpression. (D) Subcellular distribution of p53 expression in the nucleus and cytoplasm was assessed through western blotting after USP2 overexpression. (E) Localization of p53 in cells detected by fluorescence in situ hybridization (FISH) after USP2 overexpression. Scale bar = 10 μm. **p < 0.01, ***p < 0.001