Noninvasive preimplantation genetic testing for aneuploidy using blastocyst spent culture medium may serve as a backup of trophectoderm biopsy in conventional preimplantation genetic testing

Table 1 Assessment of the 146 embryos with TE biopsy PGT and niPGT-A in the study

		Family	Embryos	Average Embryos	Concordance assessments between SCM and TE biopsy
		Family	Embryos	Average Embryos	True Positive	Ture Negative	False Positive	False Negative	Concordance rate % (95%CI)
1st TE PGT	Normal Karyotype*	28	59	2.1	25	17	6	11	71.2(58.6–81.2)
	Abnormal Karyotype	23	87	3.8	56	16	6	9	82.8(73.5–89.3)
	Overall	51	146	2.5	81	33	12	20	78.1(70.7–84.0)
Adjusted for the 10 ICM blastocysts	Normal Karyotype	28	59	2.1	25	19	6	9	74.6(62.2–83.9)
	Abnormal Karyotype	23	87	3.8	56	21	6	4	88.5(80.1–93.6)
	Overall	51	146	2.5	81	40	12	13	82.9(75.9–88.1)

ISSN: 1755-8794