Table 2 The 10 strongest SNP associations with lifetime meth use in CNICS
From: A genome-wide association study of methamphetamine use among people with HIV
rs ID | Associated Gene/Region | Chr | Position | EA | NEA | EAF | P-Value (Total) | OR | 95% CI |
|---|---|---|---|---|---|---|---|---|---|
rs55725310 | SDK2 | 17 | 73437322 | A | G | 0.24 (Meta) 0.27 (AMR) 0.20 (AFR) 0.30 (EUR) | 4.95e-07 | 0.75 | 0.73, 0.78 |
rs35824117 | SDK2 | 17 | 73434952 | T | TA | 0.25 (Meta) 0.27 (AMR) 0.20 (AFR) 0.30 (EUR) | 1.25e-06 | 0.76 | 0.74, 0.79 |
rs1245582024 | - | 12 | 88340621 | A | G | 0.24 (Meta) 0.08 (AMR) 0.38 (AFR) 0.09 (EUR) | 1.48e-06 | 0.69 | 0.63, 0.76 |
rs10777105 | - | 12 | 88341917 | C | T | 0.24 (Meta) 0.08 (AMR) 0.38 (AFR) 0.09 (EUR) | 1.52e-06 | 0.69 | 0.63, 0.76 |
rs11654803 | SDK2 | 17 | 73435028 | T | C | 0.25 (Meta) 0.27 (AMR) 0.26 (AFR) 0.30 (EUR) | 1.88e-06 | 0.76 | 0.75, 0.78 |
rs731517 | LINC01095 (intergenic RNA) | 4 | 146114396 | G | A | 0.31 (Meta) 0.24 (AMR) 0.36 (AFR) 0.28 (EUR) | 1.90e-06 | 0.77 | 0.68, 0.87 |
rs1882396 | - | 2 | 190851286 | G | T | 0.34 (Meta) 0.49 (AMR) 0.29 (AFR) 0.35 (EUR) | 1.99e-06 | 0.78 | 0.74, 0.83 |
rs7439202 | ENSG…249,942 (lncRNA) | 4 | 74589224 | T | G | 0.16 (Meta) 0.12 (AMR) 0.21 (AFR) 0.10 (EUR) | 2.08e-06 | 0.70 | 0.61, 0.81 |
rs6434423 | - | 2 | 190853422 | C | T | 0.34 (Meta) 0.49 (AMR) 0.29 (AFR) 0.35 (EUR) | 2.17e-06 | 0.78 | 0.74, 0.83 |
rs146115874 | LINC01095 (intergenic RNA) | 4 | 146115874 | C | T | 0.32 (Meta) 0.24 (AMR) 0.37 (AFR) 0.28 (EUR) | 2.23e-06 | 0.77 | 0.69, 0.87 |