Table 1 Univariate and multivariate Cox regression analyses for overall survival of glioma patients in public datasets

TCGA cohort

(n = 656)

m6Ascore

2.71

2.43 ~ 3.02

< 0.001

1.79

1.47 ~ 2.17

< 0.001

 Age

1.07

1.06 ~ 1.08

< 0.001

1.04

1.03 ~ 1.06

< 0.001

WHO grade

 II

ref

-

-

ref

-

-

 III

3.11

2.02 ~ 4.78

< 0.001

1.98

1.25 ~ 3.12

0.003

 IV

19.3

12.6 ~ 29.7

< 0.001

2.48

1.33 ~ 4.63

0.004

IDH mutant

0.10

0.07 ~ 0.13

< 0.001

-

-

-

1p19q co-deletion

0.21

0.13 ~ 0.34

< 0.001

0.60

0.34 ~ 1.03

0.064

MGMTp methylation

0.30

0.23 ~ 0.40

< 0.001

0.70

0.51 ~ 0.97

0.029

CGGA cohort 1

(n = 313)

m6Ascore

1.68

1.52 ~ 1.86

< 0.001

1.43

1.20 ~ 1.71

< 0.001

 Age

1.03

1.02 ~ 1.05

< 0.001

1.01

1.0-1.02

0.104

WHO grade

 II

ref

-

-

ref

-

-

 III

4.25

2.78 ~ 6.50

< 0.001

3.65

2.31 ~ 5.76

< 0.001

 IV

9.44

6.40 ~ 13.98

< 0.001

5.68

3.65 ~ 8.86

< 0.001

IDH mutant

0.36

0.27 ~ 0.47

< 0.001

2.12

1.31 ~ 4.42

0.002

1p19q co-deletion

0.17

0.10 ~ 0.28

< 0.001

0.31

0.18 ~ 0.52

< 0.001

MGMTp methylation

0.83

0.63 ~ 1.09

0.178

-

-

-

CGGA cohort 2

(n = 668)

m6Ascore

1.68

1.52 ~ 1.51

< 0.001

1.33

1.19 ~ 1.48

< 0.001

Age

1.03

1.02 ~ 1.04

< 0.001

-

-

-

WHO grade

 II

ref

-

-

ref

-

-

 III

2.53

1.83 ~ 3.51

< 0.001

2.44

1.64 ~ 3.63

< 0.001

 IV

7.25

5.27 ~ 9.99

< 0.001

3.80

2.49 ~ 5.80

< 0.001

IDH mutant

0.30

0.25 ~ 0.38

< 0.001

-

-

-

1p19q co-deletion

0.24

0.17 ~ 0.34

< 0.001

0.42

0.28 ~ 0.65

< 0.001

MGMTp methylation

0.78

0.62 ~ 0.97

0.027

-

-

-