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Fig. 3 | BMC Medical Genomics

Fig. 3

From: m6A regulator-based molecular classification and hub genes associated with immune infiltration characteristics and clinical outcomes in diffuse gliomas

Fig. 3

Development of a multi-genes signature with prognostic significance. A, LASSO penalized regression identified eight genes with optimal prognostic contributions. B, hazard ratios of the eight prognostic genes in univariate Cox proportional hazard regression analyses. C, The correlations between the expressions of prognostic genes and m6A regulators. The genes labeled by red indicated risk genes; The genes labeled by blue indicated protected genes; The genes labeled by black indicated m6A regulators. The color of dot represented correlation coefficient; The size of dot represented p-value. D, ROC curve analysis of the m6Ascore for predictiing overall survival. E, The correlations of m6Asocre and immune socre calculated by ESTIMATE algorithm. F-H, Survival differences between high and low m6Ascore groups in all gliomas (H), GBM (I) and LGG (J) cohort. I and J, Survival differences between high and low m6Ascore groups of gliomas from the CGGA cohort 1 (I) and CGGA cohort 2 (J)

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BMC Medical Genomics

ISSN: 1755-8794

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