Fig. 1

m6A modulation patterns and clinical relevance in diffuse gliomas. A, Protein-protein interaction between m6A regulators. The circle size represented the connection strength of each node. Writers were colored by red in the circle; erasers were colored by blue; readers were colored by purple in the circle. B, Consistent clustering based on the comprehensive expression profiles of 18 m6A regulators. C, Expressions of the m6A regulators among different m6A clusters. The subtypes of gliomas were derived from previous publications by TCGA Research Network (Ceccarelli, et al. Cell, 2016). D, Principle component analysis for the transcriptome profiles of the four m6A clusters. E, The proportions of different m6A clusters in GBM and LGG. F, The survival differences of the four m6A clusters. G, The proportions of combination of chromosome 7 gain and chromosome 10 loss in the m6A-high-risk and m6A-low-risk subtypes. H-I, The frequencies of genetic alteration events in different m6A subtypes from LGG (H) and GBM (I) cohorts. J-K, Comparisons of survival between different m6A subtypes from LGG (J) and GBM (K) cohorts