Fig. 4

Correlation of IS regulatory genes with hub DEFRGs. (A) miRNA‒mRNA network diagram of hub DEFRGs. (B) Differential expression of IS regulatory genes. (C) Correlation of IS regulatory genes with hub DEFRGs showing that Nfe2l2 was significantly negatively related to Cst3 and Stat3 was significantly positively related to Icam1. *p < 0.05; **p < 0.01; ***p < 0.001; N.S., nonsignificant