Table 8 Evaluation of the gastric cancer screening panel in literature

miR-1228

It has been documented that miR-1228 is highly expressed in the serum exosomes of patients with gastric cancer and its upregulation can downregulate the expression of MMP-14 and remarkably hinder the development and progression of gastric cancer

[56]

They indicated that the expression of miR-1228 was reduced in human gastric cancer tissues compared to normal tissues. Moreover, miR-1228 acts as a negative regulator of NF-κB activity in the xenograft tumor model of gastric cancer, targets CK2A2, decreases the expression of mesenchymal markers, and increases the epithelial marker E-cadherin, suggesting it as a potential target for antiangiogenic therapy against gastric cancer

[57]

It has been proved that miR-1228 targets macrophage migration inhibitory factor (MIF), which negatively regulates gastric cancer growth and angiogenesis by downregulating MIF

The upregulation of miR-1228 decreased the expression of mesenchymal markers and increased the epithelial marker E-cadherin, suggesting its potential role in suppressing epithelial-mesenchymal transition; hence, miR-1228 plays a key role in regulating gastric cancer growth, and the selective restoration of miR-1228 may be beneficial for gastric cancer therapy

[58]

miR-1343-3p

It has earned the foremost position in the recommended panel for gastric cancer classification, showcasing outstanding precision (AUC: 100%, sensitivity: 100%, specificity: 100%, ROC: 100%)

[59]

It is also shown that LINC01559 (long intergenic non-protein coding RNA 1559) is upregulated in GC tissues, where it can be transmitted from MSCs to GC cells via exosomes and target miR-1343-3p to promote GC progression by activating the PI3K/AKT pathway

[60]

It was reported that TEAD1/4 oncogenic factors were overexpressed in GC cell lines and primary GC tissues, where TEAD4 was negatively regulated by miR-1343-3p, and its aberrant activation was mediated by silencing miR-1343-3p

[61]

hsa-miR-6787-5p

It was ranked 17th in the recent machine learning variable selection approach for gastric cancer classification

[59]

It was significantly upregulated in extracellular vesicle-miRNA profiles in metastatic cell lines under RAPA treatment compared to CsA and untreated conditions. It can be a potential epigenetic mechanism induced by RAPA therapy in regulating the premetastatic niche of posttransplant colorectal cancer

[62]

hsa-miR-6765-5p

The significant upregulation of which was the main regulator of messenger RNAs involved in the pathology of venous thrombosis

[63]