Table 7 Evaluation of the multi-cancer screening panel in literature

hsa-miR-8073

They demonstrated a significant correlation between microRNA-8073 and both the pathological stage and unfavorable prognosis of Ovarian Cancer

[37]

It has also been proposed as a novel serum miRNA discriminant model developed for the diagnosis of late-stage esophageal squamous cell carcinoma (ESCC) in analyzing 566 ESCC versus 4965 control patients without cancer

[38]

It was reported to be present in exosomes and predominantly exported from colorectal cancer cells. Some evidence suggests that miR-8073 can bind to oncogenic target candidates (FOXM1, MBD3, CCND1, KLK10, and CASP2), with antiproliferative effects

[39]

In their study to discover biomarkers for Breast cancer classification, their models achieved close to 96% accuracy in the independent validation set using miR-8073 as a single biomarker

[40]

hsa-miR-614

The expression of miR-614 in patients with gastric cancer was significantly lower than that in the control group, and the expression of miR-614 in the HGC-27 cell line inhibited the invasion and proliferation of these cells

[41]

It might serve as an antitumor target for lung cancer in the future

[42]

The upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression

[43]

Furthermore, miR-614 can inhibit the tumorigenesis of tumor cells by targeting RHOT1

[44]

It is noted that RHOT1, a novel member of the Rho family, induces the proliferation and migration of pancreatic cancer cells

[45]

It was among the most differentially expressed miRNAs regarding the diagnosis of pancreatic cancer

[46]

miR-548-3p

They showed significantly difference between the means of miR-548-3p expression between Oral squamous cell carcinoma (OSCC) and control groups

[47]

It was indicated that it plays a critical role in the occurrence and development of NSCLC, thereby affecting the proliferation and apoptosis of NSCLC cells by targeting KLF15

[48]

It can attenuate the development of CC by targeting TPX2 or inhibiting the PI3K/AKT signaling pathway in lung cancer

[42]

It serves as an invasion and metastasis regulator targeting heparanase in gastric cancer

[49]

They reported that it acts as an anti-oncogenic regulator in breast cancer

[50]

It can proliferate breast cancer cells by regulating the expression of ECHS1

[51]

It has been revealed that hsa-miR-548ah-5p targets ATG16L1, participates in the autophagy process, and has the potential to be used to manipulate autophagy in 5-FU-based chemotherapy in colon cancer cells

[52]

miR-1258

The upregulation of miR-1258 regulates the cell cycle and inhibits cell proliferation by targeting E2F8 in colorectal cancer directly

[53]

It was significantly downregulated in hepatocellular carcinoma and associated with poor patient survival. The overexpression of miR-1258 significantly inhibits liver cancer cell growth, proliferation, and tumorigenicity by increasing cell cycle arrest in the G0/G1 phase and promoting cell apoptosis

[54]

They illustrated how the miR-1258 mechanism was linked to brain metastatic breast cancer through heparanase control. They also offered the development of heparanase-based therapeutics for the treatment of cancer patients with brain metastases, especially BMBC

[55]