Table 4 Distribution of SNPs in each type of gallbladder stone group and control group
From: Relationship between mucin gene polymorphisms and different types of gallbladder stones
Type of stone | Genes | SNPs | Allele/ Genotype | Stone Group | Control | OR(95%CI) | P* value |
|---|---|---|---|---|---|---|---|
Cholesterol stone (n = 33) | MUC4 | rs712005 | G | 18(27.27%) | 39(18.22%) | 2.51(1.20–5.22) | 0.014 |
A | 48(72.73%) | 175(81.78%) | |||||
MUC5B | rs2037089 | C | 7(10.61%) | 12(5.61%) | 3.54(1.14–11.01) | 0.029 | |
T | 59(89.39%) | 202(94.39%) | |||||
MUC2 | rs2856111 | T/T | 9(27.27%) | 26(24.30%) | 3.02(0.73–12.39) | 0.126 | |
C/T | 20(60.61%) | 50(46.73%) | 3.81(1.06–13.68) | 0.040 | |||
C/C | 4(12.12%) | 31(28.97%) | - | - | |||
MUC17 | rs73168398 | A/A | 1(3.03%) | 3(2.80%) | 0.66(0.06–7.86) | 0.741 | |
G/A | 4(12.12%) | 25(23.36%) | 0.26 (0.07–0.98) | 0.046 | |||
G/G | 28(84.85%) | 79(73.83%) | - | - | |||
rs10229731 | C/C | 3(9.09%) | 4(3.74%) | 1.07(0.17–6.75) | 0.944 | ||
A/C | 8(24.24%) | 42(39.25%) | 0.33 (0.12–0.95) | 0.039 | |||
A/A | 22(66.67%) | 61(57.01%) | - | - | |||
Pigment gallstone (n = 11) | MUC6 | rs10902268 | A | 1(4.55%) | 36(16.82%) | 0.00 (0.00–0.27) | 0.011 |
G | 21(95.45%) | 178(83.18%) | |||||
rs61869016 | C | 5(22.73%) | 78(36.45%) | 0.07 (0.01–0.63) | 0.017 | ||
T | 17(77.27%) | 136(63.55%) | |||||
Mixed stone (n = 77) | MUC2 | rs41532344 | T | 16(11.76%) | 17(7.94%) | 2.55(1.06–6.13) | 0.036 |
C | 120(88.24%) | 197(92.06%) | |||||
MUC5 AC | rs28415193 | G | 45(33.09%) | 46(21.70%) | 1.77(1.02–3.07) | 0.041 | |
C | 91(66.91%) | 166(78.30%) | |||||
MUC6 | rs10902268 | A/A | 4(5.88%) | 1(0.93%) | 3.49(0.32–38.02) | 0.305 | |
G/A | 16(23.53%) | 34(31.78%) | 0.40 (0.17–0.95) | 0.038 | |||
G/G | 48(70.59%) | 72(67.29%) | - | - |