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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

Fig. 3

MN specific DNA methylation is linked to MN function but not to genetic risk for ALS. (A) We used independent measurements of MN gene expression and ALS heritability to verify the biological validity of identified MN-specific hypomethylated genomic regions. MN-specific hypomethylated genes are enriched with genes expressed in human MN (B) and in human iPSC-derived MN (C). MN-specific hypomethylated genes are not differentially expressed in ALS iPSC-derived MN compared to control MN (D)

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BMC Medical Genomics

ISSN: 1755-8794

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