The association between vitamin D receptor gene polymorphism FokI and type 2 diabetic kidney disease and its molecular mechanism: a case control study

Table 2 Comparison of VDR-FokI genotype distribution under different genetic models

		Homozygotes		Invisible model		Dominant model
		OR(95%CI)	P value	OR(95%CI)	P value	OR(95%CI)	P value
Healthy control group vs. T2DM group	Model 1	2.229(0.562–8.842)	0.254	2.562(0.715–9.178)	0.148	0.947(0.443–2.024)	0.887
Healthy control group vs. T2DM group	Model 2	4.821 (0.579–40.128)	0.146	3.540 (0.765–8.136)	0.095	1.240 (0.467–3.290)	0.666
T2DM vs. T2DKDgroup	Model 1	1.799(0.873–3.707)	0.112	1.631(0.874–3.043)	0.124	1.307(0.765–2.233)	0.327
T2DM vs. T2DKDgroup	Model 3	2.930 (1.142–7.513)	0.025	2.009 (1.008–4.006)	0.048	1.404 (0.769–2.565)	0.269

Model 1: Univariate logistic regression analysis
Model2: Adjusted for age, serum uric acid, TC, TG, LDL-C, HDL-C, FPG
Model 3: Adjusted for diabetes course, hypertension history, HbA1c, serum uric acid, TC, TG, LDL-C and HDL-C
Homozygotes: T/T vs. C/C (ff vs. FF); Invisible model; T/T vs. C/C + C/T (ff vs. FF + Ff): Dominant model; C/T + T/T vs. C/C (Ff + ff vs. FF)

ISSN: 1755-8794