Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

Table 7 Meta-analysis of maternal MTHFD1 gene G1958A polymorphism and the risk of congenital heart disease in offspring

Type	OR(95%CI)	z	P	Test of heterogeneity		Analysis model
Type	OR(95%CI)	z	P	I²	P^*	Analysis model
Overall(5)
GA VS GG	1.22[1.04,1.42]	2.45	0.01	0%	0.84	Fixed-effects model
AA VS GG	1.02[0.72,1.43]	0.09	0.93	0%	0.55	Fixed-effects model
GA + AA VS GG	1.17[1.01,1.34]	2.15	0.03	0%	0.71	Fixed-effects model
AA VS GG + GA	0.94[0.68,1.31]	0.35	0.73	0%	0.61	Fixed-effects model
A VS G	1.12[0.99,1.26]	1.74	0.08	0%	0.44	Fixed-effects model
SD(3)
GA VS GG	0.98[0.64,1.49]	0.10	0.92	0%	0.92	Fixed-effects model
AA VS GG	0.53[0.25,1.12]	1.67	0.10	0%	0.62	Fixed-effects model
GA + AA VS GG	0.93[0.68,1.28]	0.43	0.67	0%	0.90	Fixed-effects model
AA VS GG + GA	0.54[0.27,1.08]	1.73	0.08	0%	0.62	Fixed-effects model
A VS G	0.82[0.61,1.11]	1.26	0.21	0%	0.90	Fixed-effects model
yellow race(3)
GA VS GG	1.22[1.04,1.44]	2.38	0.02	0%	0.67	Fixed-effects model
AA VS GG	1.01[0.69,1.49]	0.05	0.96	6%	0.35	Fixed-effects model
GA + AA VS GG	1.20[1.02,1.40]	2.24	0.03	0%	0.47	Fixed-effects model
AA VS GG + GA	0.95[0.65,1.39]	0.28	0.78	0%	0.4	Fixed-effects model
A VS G	1.13[0.99,1.29]	1.79	0.07	19%	0.29	Fixed-effects model
white race(2)
GA + AA VS GG	1.05[0.76,1.45]	0.31	0.76	0%	0.7	Fixed-effects model

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