Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

Yi, Kang; He, Shao-E; Guo, Tao; Wang, Zi-Qiang; Zhang, Xin; Xu, Jian-Guo; Zhang, Hao-Yue; Liu, Wei-Guo; You, Tao

doi:10.1186/s12920-024-02052-w

Table 6 Meta-analysis of fetal MTHFD1 gene G1958A polymorphism and its risk of congenital heart disease

From: Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

Type	OR(95%CI)	z	P	Test of heterogeneity		Analysis model
Type	OR(95%CI)	z	P	I²	P^*	Analysis model
Overall(7)
GA VS GG	1.07[0.92,1.24]	0.89	0.37	3%	0.40	Fixed-effects model
AA VS GG	1.15[0.67,1.96]	0.51	0.61	63%	0.02	Random-effects model
GA+AA VS GG	1.05[0.83,1.32]	0.38	0.70	61%	0.02	Random-effects model
AA VS GG+GA	1.09[0.67,1.78]	0.36	0.72	58%	0.04	Random-effects model
A VS G	1.13[0.91,1.41]	1.08	0.28	68%	0.008	Random-effects model
ASD(4)
GA VS GG	1.01[0.60,1.70]	0.03	0.97	10%	0.33	Fixed-effects model
AA VS GG	1.58[0.64,3.95]	0.99	0.32	31%	0.23	Fixed-effects model
GA+AA VS GG	1.34[0.86,2.07]	1.30	0.19	39%	0.18	Fixed-effects model
AA VS GG+GA	1.52[0.64,3.63]	0.95	0.34	0%	0.37	Fixed-effects model
A VS G	1.10[0.53,2.26]	0.25	0.80	62%	0.07	Random-effects model
VSD(4)
GA VS GG	1.06[0.82,1.37]	0.44	0.66	0%	0.59	Fixed-effects model
AA VS GG	0.83[0.47,1.49]	0.62	0.54	0%	0.50	Fixed-effects model
GA+AA VS GG	1.34[0.86,2.10]	1.29	0.20	63%	0.04	Random-effects model
AA VS GG+GA	0.80[0.45,1.40]	0.78	0.44	0%	0.67	Fixed-effects model
A VS G	0.99[0.81,1.20]	0.15	0.88	0%	0.52	Fixed-effects model
SD(5)
GA VS GG	1.04[0.82,1.33]	0.33	0.74	0%	0.59	Fixed-effects model
AA VS GG	0.90[0.53,1.53]	0.38	0.70	0%	0.45	Fixed-effects model
GA+AA VS GG	1.14[0.80,1.63]	0.71	0.48	60%	0.04	Random-effects model
AA VS GG+GA	0.87[0.52,1.45]	0.54	0.59	0%	0.63	Fixed-effects model
A VS G	1.00[0.83,1.20]	0.04	0.97	0%	0.49	Fixed-effects model
TOF(3)
GA VS GG	0.73[0.37,1.46]	0.89	0.37	0%	0.33	Fixed-effects model
AA VS GG	2.82[1.16,6.86]	2.28	0.02	0%	0.43	Fixed-effects model
GA+AA VS GG	1.16[0.68,1.99]	0.55	0.59	20%	0.29	Fixed-effects model
AA VS GG+GA	3.09[1.36,7.03]	2.69	0.007	0%	0.53	Fixed-effects model
A VS G	1.27[0.62,2.59]	0.66	0.51	54%	0.14	Random-effects model
yellow race(4)
GA VS GG	1.02[0.87,1.19]	0.26	0.79	0%	0.72	Fixed-effects model
AA VS GG	0.77[0.54,1.08]	1.51	0.13	0%	0.70	Fixed-effects model
GA+AA VS GG	0.99[0.85,1.15]	0.17	0.86	0%	0.69	Fixed-effects model
AA VS GG+GA	0.76[0.54,1.07]	1.56	0.12	0%	0.74	Fixed-effects model
A VS G	0.96[0.84,1.08]	0.72	0.47	0%	0.68	Fixed-effects model
white race(3)
GA VS GG	1.46[0.97,2.20]	1.80	0.07	23%	0.26	Fixed-effects model
AA VS GG	2.84[1.47,5.49]	3.11	0.002	0%	0.43	Fixed-effects model
GA+AA VS GG	1.08[0.82,1.43]	0.55	0.59	85%	0.001	Random-effects model
AA VS GG+GA	2.44[1.31,4.55]	2.82	0.005	0%	0.49	Fixed-effects model
A VS G	1.74[1.09,2.78]	2.31	0.02	58%	0.12	Random-effects model
Asia(5)
GA VS GG	1.06[0.91,1.23]	0.74	0.46	19%	0.29	Fixed-effects model
AA VS GG	0.97[0.57,1.65]	0.10	0.92	54%	0.07	Random-effects model
GA+AA VS GG	1.09[0.86,1.38]	0.71	0.48	54%	0.07	Random-effects model
AA VS GG+GA	0.88[0.64,1.21]	0.77	0.44	45%	0.13	Fixed-effects model
A VS G	1.08[0.85,1.37]	0.65	0.52	68%	0.01	Random-effects model

Back to article page

ISSN: 1755-8794

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Medical Genomics

Contact us