Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

Yi, Kang; He, Shao-E; Guo, Tao; Wang, Zi-Qiang; Zhang, Xin; Xu, Jian-Guo; Zhang, Hao-Yue; Liu, Wei-Guo; You, Tao

doi:10.1186/s12920-024-02052-w

Table 4 Genotype characteristics of included studies.(children with CHD and its subgroups)

From: Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

First author	Total	GG	GA	AA	GA+AA	Total	GG	GA	AA	GA+AA	Allele frequencies cases		Allele frequencies controls
First author	Total	GG	GA	AA	GA+AA	Total	GG	GA	AA	GA+AA	G	A	G	A
ASD
Cheng	22	17	5	0	5	122	76	40	6	46	0.886	0.114	0.787	0.213
Xu	41	21	17	3	23	527	289	210	28	238	0.72	0.28	0.748	0.252
Christensen	11	2	6	3	9	110	43	56	11	67	0.455	0.545	0.645	0.355
Khatami	24	15	–	–	9	98	73	–	–	25	–	–	–	–
VSD
Cheng	88	52	32	4	36	122	76	40	6	46	0.773	0.227	0.787	0.213
Xu	257	145	103	9	112	527	289	210	28	238	0.765	0.235	0.748	0.252
Christensen	43	13	25	5	30	110	43	56	11	67	0.593	0.407	0.645	0.355
Khatami	63	33	–	–	30	98	73	–	–	25	–	–	–	–
SD
Cheng	110	69	37	4	41	122	76	40	6	46	0.795	0.205	0.787	0.213
Xu	298	166	120	12	132	527	289	210	28	238	0.758	0.242	0.748	0.252
Christensen	63	19	36	8	44	110	43	56	11	67	0.587	0.413	0.645	0.354
Kuzelicki	90	31	–	–	59	198	54	–	–	144	–	–	–	–
Khatami	87	48	–	–	39	98	73	–	–	25	–	–	–	–
TOF
Cheng	22	16	4	2	6	122	76	40	6	46	0.818	0.182	0.787	0.213
Christensen	35	11	14	10	24	110	43	56	11	67	0.514	0.486	0.645	0.355
Khatami	15	9	–	–	6	98	73	–	–	25	–	–	–	–
yellow race
Cheng	179	108	64	7	71	122	76	40	6	46	0.782	0.218	0.787	0.213
Xu	502	291	195	16	211	527	289	210	28	238	0.774	0.226	0.748	0.252
Wang	160	94	53	13	66	188	109	64	15	79	0.753	0.247	0.75	0.25
Liu	620	393	201	26	227	620	403	185	32	217	0.8	0.2	0.8	0.2
white race
Christensen	158	50	78	30	108	110	43	56	11	67	0.563	0.437	0.645	0.355
Kuzelicki	196	74	–	–	122	198	54	–	–	144	–	–	–	–
Khatami	102	57	32	13	45	98	73	21	4	25	0.716	0.284	0.852	0.148
Asia
Cheng	179	108	64	7	71	122	76	40	6	46	0.782	0.218	0.787	0.213
Xu	502	291	195	16	211	527	289	210	28	238	0.774	0.226	0.748	0.252
Wang	160	94	53	13	66	188	109	64	15	79	0.753	0.247	0.75	0.25
Khatami	102	57	32	13	45	98	73	21	4	25	0.716	0.284	0.852	0.148
Liu	620	393	201	26	227	620	403	185	32	217	0.796	0.204	0.799	0.201

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