Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

Table 3 Genotype characteristics of included studies

First author	Case				GA+AA	Control				GA+AA	Allele frequencies cases		Allele frequencies controls
First author	Total	GG	GA	AA	GA+AA	Total	GG	GA	AA	GA+AA	G	A	G	A
Fetal group
Cheng	179	108	64	7	71	122	76	40	6	46	0.782	0.218	0.787	0.213
Xu	502	291	195	16	211	527	289	210	28	238	0.774	0.226	0.748	0.252
Wang	160	94	53	13	66	188	109	64	15	79	0.753	0.247	0.75	0.25
Christensen	158	50	78	30	108	110	43	56	11	67	0.563	0.437	0.645	0.355
Kuzelicki	196	74	–	–	122	198	54	–	–	144	–	–	–	–
Khatami	102	57	32	13	45	98	73	21	4	25	0.716	0.284	0.852	0.148
Liu	620	393	201	26	227	620	403	185	32	217	0.796	0.204	0.799	0.201
Maternal group
Cheng	177	96	73	8	81	119	62	47	10	57	0.749	0.251	0.718	0.281
Christensen	199	59	106	34	140	105	34	52	19	71	0.563	0.437	0.571	0.429
Kuzelicki	195	67	–	–	128	198	68	–	–	130	–	–	–	–
Song	464	286	158	20	178	504	332	152	20	172	0.787	0.213	0.81	0.19
Chen	683	420	238	25	263	740	495	219	26	245	0.789	0.211	0.817	0.183

ISSN: 1755-8794