Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis

Table 1 Characteristics of studies included

First author	Year	Country	Region	Race	Genotyping method	Type of disease	Control source	PHWE
Cheng	2005	China	East Asian	Chinese Han	PCR-RFLP	ASD VSD PDA TOF	HB	0.804
Xu	2010	China	East Asian	Chinese Han	proteinase K digestion	PDA SD LVOTO	HB	0.199
Wang	2013	China	East Asian	Chinese Han	SNaPShot Sanger	CHD	HB	0.206
Christensen	2008	Canada	North America	N. European	proteinase K digestion	SD CTD VD	HB	0.239
Kuzelicki	2022	Slovenia	South-central Europe	Caucasian	TaqMan probes	SD CTD LVOTO	HB	NA
Khatami	2017	Iran	Southwest Asian	Iranian	PCR-RFLP	ASD VSD TOF	HB	0.137
Song	2022	China	East Asian	Chinese Han	MassARRAY	ASD VSD TOF CTD	HB	0.620
Liu	2023	China	East Asian	Chinese Han	MassARRAY	ASD VSD PDA	HB	0.080
Chen	2022	China	East Asian	Chinese Han	MassARRAY	CHD	HB	0.770

CHD – congenital heart disease; HWE – Hardy Weinberge equilibrium; TGA – transposition of the great arteries; ASD-Atrial Septal Defect; VSD- Ventricular Septal Defect; SD- Septal Defect; PDA- Patent Ductus Arteriosus; TOF – tetralogy of fallot; LVOTO- left ventricular outflow tract obstruction. CTD – conotruncal heart defects; PCR-RFLP- polymerase chain reaction-restriction fragment length polymorphism; PB – population-based; HB – hospital-based; NA – notavailable; PHWE: P value of HWE of the control group, PHWE > 0.05 means that the control group conforms to Hardy–Weinberg equilibrium, and the research is meaningful

ISSN: 1755-8794