Table 3 Details of SMN1 or SMN2 copy number groups
From: SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan
SMN1:SMN2 copies | Control (n = 399) | ALS (n = 487) | LMND (n = 50) | Control vs. ALS OR (95% CI) | Control vs. LMND OR (95% CI) |
|---|---|---|---|---|---|
1:1 | 3 (0.8%) | 1 (0.2%) | 0 | 0.27 (0.02–1.83) | - |
1:2 | 1 (0.3%) | 3 (0.6%) | 0 | 2.46 (0.37-32.0) | - |
1:3 | 1 (0.3%) | 0 | 0 | - | - |
2:0 | 14 (3.5%) | 29 (6.0%) | 4 (8.0%) | 1.74 (0.90–3.28) | 2.39 (0.83–7.33) |
2:1 | 103 (25.8%) | 168 (34.5%) | 13 (26.0%) | 1.51 (1.13–2.03)* | 1.01 (0.51-2.00) |
2:2 | 242 (60.7%) | 254 (52.2%) | 29 (58.0%) | 0.70 (0.54–0.93)* | 0.90 (0.50–1.62) |
2:3 | 5 (1.3%) | 7 (1.4%) | 1 (2.0%) | 1.15 (0.40–3.22) | 1.61 (0.13–12.1) |
3:0 | 4 (1.0%) | 3 (0.6%) | 1 (2.0%) | 0.61 (0.15–2.29) | 2.02 (0.16–12.5) |
3:1 | 17 (4.3%) | 16 (3.3%) | 1 (2.0%) | 0.76 (0.40–1.57) | 0.46 (0.04–2.76) |
3:2 | 7 (1.8%) | 3 (0.6%) | 0 | 0.35 (0.10–1.24) | - |
4:0 | 1 (0.3%) | 3 (0.6%) | 1 (2.0%) | 2.47 (0.37–32.1) | 8.12 (0.42–154.5) |
4:2 | 1 (0.3%) | 0 | 0 | - | - |