Fig. 2

End motifs of plasma DNA in patients with critical COVID-19. A Heatmap analysis of motif frequencies in patients with COVID-19 (alive: n = 16, deceased: n = 17). The frequencies were normalized by calculating z-scores for the rows. B Box plot of motif diversity score (MDS) among alive (n = 16) and deceased (n = 17) patients. C-F Box plot analysis of 4 representative motifs showing differences in terms of frequency between the alive and deceased groups. G ROC curve analysis between alive and deceased groups by using MDS and the occurrence of 4 representative motifs