Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality

Table 5 Distribution of the compound genotypes for the two DBP gene variations (haplotypes analysis) between the two studied groups

Haplotypes name	Combination of rs7041 and rs4588 genotypes	COVID-19 patients (n = 140)	Controls (n = 80)	Total (N = 220)	χ2	P-value
1 F–1 F	TT CC	22 (15.7%)	8 (10%)	30 (13.6%)	0.138	0.299
1 F-1 S	TG CC	38 (27.1%)	23 (28.8%)	61(27.8%)	6.984	0.009*
1 F-2	TT CA	14 (10%)	9 (11.2%)	23(10.4%)	0.060	0.125
1 S–1 S	GG CC	28 (20%)	12 (15%)	40(18.1%)	0.215	0.0601
1 S-2	TG CA	34 (24.3%)	24 (30%)	58(26.4%)	7.982	0.003*
2–2	TT AA	4 (2.9%)	4 (5%)	8(3.7%)	1.237	0.487

χ2: Chi-square test, the p-value for comparing between the two studied groups. Variables presented as number of patients (percent), *: Statistically significant at p ≤ 0.05

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