Fig. 5
From: CLN3 transcript complexity revealed by long-read RNA sequencing analysis
The same CLN3 open reading frames (ORFs) are associated with different 5' untranslated regions (5’UTRs) and 3' untranslated regions (3’UTRs). The presence of untranslated regions (UTRs) for three selected CLN3 ORFs is plotted; UTRs with tissue-specific expression are shown in orange, and non-tissue-specific UTRs are shown in black. The usage of these UTRs (with specific ORFs) in different tissues is plotted using heat maps with yellow showing high usage and dark blue showing low usage. Cell lines are grouped together and shown separately. A Twenty-three different 5’UTRs were found with the canonical CLN3 ORF “CLN3_24_438aa”, 16 of them show additional upstream exons, 11 of them show tissue-specificity; B Three different 3’UTRs were identified with the canonical ORF “CLN3_24_438aa”, none of them shows tissue-specificity. The distal 3’UTR, “3UTR_49”, is specific to the canonical ORF