Fig. 1
From: CLN3 transcript complexity revealed by long-read RNA sequencing analysis
Summary of key findings. From 99 ENCODE long-read RNA sequencing samples, 172 CLN3 transcripts are detected, of which 147 of them are novel. We are also able to detect the ‘major’ disease-associated transcripts (‘Δex7/8’) across 22 samples and transcripts matching a reported ASO-induced exon skipping (‘Δex5/7/8’) across 15 samples. Amongst all CLN3 transcripts detected, 26 novel open reading frames (ORFs), 69 novel 5' untranslated regions (5’UTRs) and 23 novel 3' untranslated regions (3’UTRs) are identified