Table 2 Changes in the free energy of binding between PPP1R12A and PP1C proteins
From: Functional analysis of a novel nonsense PPP1R12A variant in a Chinese family with infantile epilepsy
Contributors | PPP1R12A (wild-type)–PP1C binding energy (kJ/mol) | PPP1R12A (Arg845Ter)–PP1 binding energy (kJ/mol) |
|---|---|---|
△van der Waals interaction energy | –187.02 ± 1.24 | –105.12 ± 1.87 |
△electrostatic energy | –29.08 ± 0.22 | –29.77 ± 0.54 |
△polar solvation energy | 76.69 ± 1.26 | 78.19 ± 1.22 |
△non-polar solvation energy | –31.23 ± 0.96 | –28.19 ± 0.43 |
△binding free energy | –170.64 ± 1.26 | –84.89 ± 1.88 |