Fig. 4
From: Exploring novel MYH7 gene variants using in silico analyses in Korean patients with cardiomyopathy
In silico predictive scores of MYH7 variants. Comparison of predicted pathogenicity scores for pathogenic (P)/likely pathogenic (LP) and VUS (variants of uncertain significance)/novel missense MYH7 variants in this study, with missense variants identified in OMIM. The scatter dot plots show the values for various predictive scores: (a) SIFT, (b) Mutation assessor, (c) PROVEAN, (d) PolyPhen-2, (e) CADD (GRCh38-v1.6), (f) REVEL, (g) MetaLR, (h) MetaRNN, and (i) MetaSVM scores. The pathogenicity score threshold based on a previous study [41] is presented in the gray area of each graph. Data are presented as the mean ± standard deviation. Statistical significance in e, f, h, and i was calculated using ordinary one-way ANOVA in GraphPad Prism 8.0.2. * = p < 0.05