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Table 1 Characteristics of the study groups

From: Serum lncRNA ITGB2-AS1 and ICAM-1 as novel biomarkers for rheumatoid arthritis and osteoarthritis diagnosis

Parameter

Healthy controls

(n = 22)

RA

(n = 43)

Knee OA

(n = 35)

P-value

Age (years)

55.29 ± 5.33

52.44 ± 3.69

56.51 ± 5.51b

0.0009

Sex, n (%)

Female

Male

20 (90.90)

2 (9.10)

42 (97.67)

1 (2.33)

33 (94.28)

2 (5.72)

0.48

ESR (mm/h)

14 (12–16)

40 (30–51)a

12 (8–17)b

< 0.0001

CRP (mg/L)

3 (2.85–3.90)

10 (6–40)a

3 (2.7-4.0)b

< 0.0001

RF (≥ 15 IU/mL)

Mean ± SD

0 (0)

6.3 ± 2.00

34 (79)

37.83 ± 23.89a

0 (0)

5.57 ± 2.00b

< 0.0001

Disease activity#, n (%)

Low

Moderate

High

 

4 (9.3)

15 (34.9)

24 (55.8)

 

-

Disease severity$, n (%)

Mild

Moderate

Severe

-

-

14 (40.0)

16 (45.7)

5 (14.3)

-

  1. Data are presented as mean ± SD, median (25−75% percentiles), or number (percentage) when appropriate. P-values of one-way ANOVA, Kruskal-Wallis, or X2 tests are presented. a significant difference from the control group; b significant difference from the RA group. Bold indicates statistical significance, P < 0.05. CRP, C-reactive protein; DAS28, disease activity score 28-joint count; ESR, erythrocyte sedimentation rate; KL, Kellgren–Lawrence score; OA, osteoarthritis; RA, rheumatoid arthritis; RF, rheumatoid factor. #RA disease activity: low DAS28 = 2.6 to < 3.1, moderate DAS28 = 3.1 to < 5.1, and high DAS28 ≥ 5.1. $Knee OA disease severity: mild KL = 2, moderate KL = 3, severe KL = 4