NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

BMC Medical Genomics

Table 6 Association analysis between gene locus polymorphisms and the risk of IS

SNPs	Model	Genetic typing	Physical examination group	The IS group	OR (95% CI)	P
	Codominant model	TT	51	33	Ref
		GT	45	83	0.351[0.199–0.620]	< 0.001
		GG	28	27	0.671[0.338–1.333]	0.255
	The dominant model	TT	51	33	Ref
	The dominant model	GT + GG	73	110	0.429[0.253–0.728]	0.002
rs689455	Recessive model	TT + GT	96	116	Ref
	Recessive model	GG	28	27	1.253[0.692–2.269]	0.456
	Overdominant model	GG + TT	79	60	Ref
	Overdominant model	GT	45	83	0.412[0.251–0.675]	< 0.001
	allele model	T	147	149	Ref
	allele model	G	101	137	0.747[0.530–1.054]	0.096
	Codominant model	CC	51	34	Ref
	Codominant model	CT	42	80	0.350[0.197–0.620]	< 0.01
	The dominant model	TT	31	29	0.713[0.366–1.388]	0.319
		CC	51	34	Ref
		CT + TT	73	109	0.446[0.264–0.755]	0.003
rs1800566	Recessive model	CC + CT	93	114	Ref
	Recessive model	TT	31	29	1.310[0.737–2.330]	0.357
	Overdominant model	TT + CC	82	63	Ref
	Overdominant model	CT	42	80	0.403[0.245–0.663]	< 0.001
	allele model	C	144	148	Ref
	allele model	T	104	138	0.775[0.550–1.091]	0.144
	Codominant model	CC	52	65	Ref
		CT	53	68	0.974[0.584–1.625]	0.920
		TT	19	10	2.375[1.017–5.546]	0.046
	The dominant model	CC	52	65	Ref
	The dominant model	CT + TT	72	78	1.154[0.710–1.875]	0.563
rs2917673	Recessive model	CC + CT	105	133	Ref
	Recessive model	TT	19	10	2.407[1.073–5.396]	0.033
	Overdominant model	TT + CC	71	75	Ref
	Overdominant model	CT	53	68	0.823[0.507–1.336]	0.431
	allele model	C	157	198	Ref
	allele model	T	91	88	1.304[0.910–1.870]	0.148

SNP Single nucleotide polymorphism, IS Ischemic stroke, OR Odds ratio, 95% CI 95% confidence interval

ISSN: 1755-8794