Fig. 4
From: Shared etiology of Mendelian and complex disease supports drug discovery
Combination of comorbidity and genetic similarity prioritizes candidate drugs for cancers with higher probability of success. (A) Odds ratio of success for candidate drugs supported by comorbidity or comorbidity and genetic similarity between Mendelian disease and cancer. Information about genetic similarity comes from Melamed et al. [16]. Black bars represent the 95% confidence intervals. (B) Number of comorbid and genetically similar pairs among 60 Mendelian diseases and 10 cancers. Genetic similarity was estimated using two metrics established here: gene overlap and co-expression. (C) Percentage of candidate drug-cancer pairs to be currently investigated or indicated among different levels of support