Fig. 3
From: Shared etiology of Mendelian and complex disease supports drug discovery
Highly drugged Mendelian diseases are a better resource for candidate drugs. (A) Histogram of the number of drugs targeting a Mendelian disease, for Mendelian diseases targeted by at least one drug (n = 68). (B) Mendelian diseases that significantly predict candidate drugs already investigated or indicated for their comorbid complex diseases are targeted by a higher number of drugs compared to the other Mendelian diseases (p = 9.1e-05, one-sided Wilcoxon rank-sum test comparing the number of drugs in each group). (C) Histogram of number of drugs targeting a Mendelian gene, for genes targeted by at least one drug (n = 193). (D) Genes linked to Mendelian diseases that significantly predict candidate drugs already investigated or indicated for their comorbid complex diseases are targeted by a higher number of drugs compared to the other genes (p = 2.3e-05, one-sided Wilcoxon rank-sum test comparing the number of drugs in each group)